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Amines REACH

N-methylmorpholine

CAS Number
109-02-4
EC Number
203-640-0
Chemical Formula
C5H11NO
Molecular Weight
101.15 g/mol

Description

N-methylmorpholine (CAS 109-02-4 ), commonly abbreviated as NMM, is a tertiary amine solvent and catalyst used across pharmaceutical synthesis, polymer processing, and specialty coatings. It functions primarily as a base catalyst and reaction solvent where controlled basicity and miscibility with water and organic media are required for process efficiency in industrial settings. In pharmaceutical manufacturing, NMM acts as a non-nucleophilic base in peptide coupling reactions, enabling cleaner synthesis of active pharmaceutical ingredients at scale for global distribution. Polyurethane foam and elastomer producers use it as a catalyst to control gel and blow reaction timing, directly affecting final product density and mechanical performance in various applications. In coatings and adhesive formulations, it promotes crosslinking and improves adhesion to difficult substrates, particularly in industrial and protective coating systems used in harsh environments. Printing ink manufacturers incorporate NMM as a co-solvent to improve pigment dispersion and resin compatibility in high-performance ink systems designed for modern commercial printing needs. N-methylmorpholine is supplied as a liquid in standard bulk quantities including drums and IBC containers, with smaller packaging available for laboratory and specialty use by researchers. Technical grade is the most common commercial specification, with high-purity grades available to meet pharmaceutical manufacturing requirements and specific quality standards for regulated use. Contact us for supply of N-methylmorpholine Request Quote

Other Names (Synonyms)

4-Methylmorpholine | Morpholine, 4-methyl- | 1-Methylmorpholine | 11P91ANU5X | RefChem:99901 | NMM

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point−66 °C(lit.)
Boiling Point115 °C
Density0.91406 g/cm³ @ Temp: 25.00 °C
Flash Point75 °F
Appearanceclear liquid
ColorClear
FormLiquid
Water Solubility>500 g/L (20 ºC)
Vapor Pressure18 mm Hg ( 20 °C)
Refractive Indexn 20/D 1.435(lit.)
pH10.6 (50g/l, H2O, 20℃)
Log P-0.32 at 25℃

Safety & Handling

Danger
GHS02· FlammableGHS05· CorrosiveGHS07· Irritant

Hazard Statements

H225Highly Flammable liquid and vapor
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H332Harmful if inhaled

Precautionary Statements

P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P235Store in a well-ventilated place. Keep cool.
P331Rinse mouth. Do NOT induce vomiting.
P354IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29349990
UN Number2535
ADR Class3
Packing GroupII
WGK (Germany)1