HomeProducts

n-methylpiperazine

CAS Number
109-01-3
EC Number
203-639-5
Chemical Formula
C5H12N2
Molecular Weight
100.16 g/mol

Description

N-Methylpiperazine (CAS 109-01-3 ) is a cyclic diamine building block used across pharmaceutical synthesis, polymer chemistry, and industrial process chemistry. Its secondary and tertiary amine groups make it a reactive intermediate for constructing drug molecules. In pharmaceutical manufacturing, it serves as a key structural component in the synthesis of active pharmaceutical ingredients, including several antipsychotics, antivirals, and antibiotics where the piperazine ring is incorporated. Polymer and epoxy formulators use it as a curing agent and cross-linker, where controlled reactivity with epoxide groups influences network density and final mechanical properties in industrial applications. In water treatment, it functions as a biocide intermediate and corrosion inhibitor precursor, contributing to formulations that control microbial growth in industrial cooling and process water systems. Catalyst manufacturers also use it as a ligand precursor and amine catalyst in polyurethane and specialty polymer production, providing essential functionality for high-performance chemical manufacturing. N-Methylpiperazine is supplied as a colorless to pale yellow liquid in drum and IBC quantities, with bulk tanker options available for high-volume industrial buyers requiring consistent supply chains. Standard commercial grades include technical grade and pharmaceutical-grade material meeting specifications relevant to API intermediate production. Purity levels typically range from 98% to 99%+ depending on the application. Contact us for supply of n-methylpiperazine Request Quote

Other Names (Synonyms)

1-methylpiperazine | PIPERAZINE, 1-METHYL- | B92I95EL9Q | RefChem:434645

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-6 °C
Boiling Point138 °C
Density0.88607 g/cm³ @ Temp: 40.00 °C
Flash Point108 °F
Appearanceclear liquid
ColorClear
FormLiquid
Water Solubilitysoluble
Vapor Pressure12 hPa (20 °C)
Refractive Indexn 20/D 1.466(lit.)
pH11-12 (50g/l, H2O, 20℃)
Log P-0.57 at 25℃

Safety & Handling

Danger
GHS02· FlammableGHS05· CorrosiveGHS06· ToxicGHS07· Irritant

Hazard Statements

H226Flammable liquid and vapor
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H318Causes serious eye damage
H330Fatal if inhaled
H331Toxic if inhaled
H332Harmful if inhaled

Precautionary Statements

P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284In case of inadequate ventilation wear respiratory protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P233Store in a well-ventilated place. Keep container tightly closed.
P235Store in a well-ventilated place. Keep cool.
P331Rinse mouth. Do NOT induce vomiting.
P354IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29335995
UN Number2734
ADR Class8
Packing GroupII
Storage Class3 - Flammable liquids
WGK (Germany)2