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Amines REACH

Piperazine

CAS Number
110-85-0
EC Number
203-808-3
Chemical Formula
C4H10N2
Molecular Weight
86.14 g/mol

Description

Piperazine (CAS 110-85-0 ), also known commercially as Vermizine, is a cyclic diamine used as a reactive building block and process chemical across pharmaceutical manufacturing and polymer production. Its bifunctional amine structure makes it a reliable intermediate for synthesizing active pharmaceutical ingredients and specialty materials. In pharmaceutical manufacturing, it serves as a key structural unit. This chemical is used in the synthesis of numerous drug compounds, including antipsychotics, antihistamines, and antiparasitic agents. Polymer chemists use it as a curing agent and cross-linker in epoxy resin systems. Controlled amine reactivity determines final mechanical performance in these systems. It also functions as a monomer in the production of polyamide membranes used in water treatment and industrial filtration. In agrochemical synthesis, piperazine derivatives are incorporated into fungicide and pesticide formulations as core intermediates. This versatility makes it a staple in modern chemical manufacturing processes. The product is supplied as white crystalline flakes or anhydrous powder, with piperazine hexahydrate available as an alternative hydrated form. Standard commercial grades include pharmaceutical-grade material. The material meets USP and BP specifications, as well as technical-grade product for industrial polymer and chemical synthesis applications. Bulk quantities are typically offered in multi-kilogram bags. These drums are suited to industrial procurement volumes and large-scale manufacturing needs. The material is handled according to strict safety protocols to ensure consistent quality and performance in all applications. Contact us for supply of Piperazine Request Quote

Other Names (Synonyms)

Vermizine (tn) | Piperazin | 1,4-Diazinane | 1,4-Diazacyclohexane | Antiren

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point106 °C
Boiling Point146 °C @ Press: 760 Torr
Density1.1 g/cm³
Flash Point65 °C
AppearanceSolid
ColorWhite to slightly yellow
Odorat 0.10 % in dipropylene glycol. ammoniacal
FormCrystalline Flakes
Water Solubility150 g/L (20 ºC)
Vapor Pressure0.8 mm Hg ( 20 °C)
Refractive Index1.4460
pH11.0-12.5 (25℃, 0.1M in H2O)
Log P-1.24 at 20-25℃

Safety & Handling

Danger
GHS05· CorrosiveGHS08· Health HazardGHS02· FlammableGHS07· Irritant

Hazard Statements

H228Flammable solid
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H318Causes serious eye damage
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
H371May cause damage to organs
H372Causes damage to organs through prolonged or repeated exposure
H373May causes damage to organs through prolonged or repeated exposure
H402Harmful to aquatic life

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284In case of inadequate ventilation wear respiratory protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P403Store in a well-ventilated place.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P316Get emergency medical help immediately.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P233Store in a well-ventilated place. Keep container tightly closed.
P331Rinse mouth. Do NOT induce vomiting.
P354IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29335900
UN Number2579
ADR Class8
Packing GroupIII
Storage Class4.1B - Flammable solid hazardous materials
WGK (Germany)1