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Amines REACH

Morpholine

CAS Number
110-91-8
EC Number
203-815-1
Chemical Formula
C4H9NO
Molecular Weight
87.12 g/mol

Description

Morpholine (CAS 110-91-8 ) is a cyclic amine and ether used across industrial chemistry as a corrosion inhibitor, chemical intermediate, and curing agent. Its dual amine-ether functionality makes it a building block for a broad range of downstream synthesis applications. In steam boiler and water treatment systems, morpholine is dosed to neutralize carbonic acid and suppress corrosion in condensate return lines. It serves as a well-established alternative to volatile amines in these environments. Pharmaceutical manufacturers use it as a synthetic intermediate in the production of active ingredients, where its secondary amine group enables targeted derivatization. This versatility is critical for complex chemical synthesis. In rubber and polymer processing, morpholine-based accelerators and crosslinkers improve cure rates and mechanical performance in finished elastomer products. These additives are essential for high-performance industrial rubber goods. Metalworking fluid formulators incorporate morpholine as a pH buffer and biocide component to extend fluid service life. This helps control microbial growth in demanding cutting and grinding operations across the manufacturing sector. Morpholine is supplied as a clear liquid in standard drum, IBC, and bulk tanker quantities. Technical grade is the primary commercial form, with high-purity grades available for specialized pharmaceutical synthesis applications. Buyers should confirm purity specifications and water content when sourcing for API intermediate use. Ensuring the material meets specific industrial requirements is vital for maintaining process stability and final product quality. Contact us for supply of Morpholine Request Quote

Other Names (Synonyms)

tetrahydro-p-oxazine | tetrahydro-1,4-oxazine | diethylene oximide | diethylene imidoxide | 1-Oxa-4-azacyclohexane | Diethylenimide oxide | Diethyleneimide oxide | Drewamine

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-4.9 °C
Boiling Point128.9 °C @ Press: 760 Torr
Density1.0007 g/cm³ @ Temp: 20 °C
Flash Point96 °F
AppearanceMorpholine is a colorless liquid with a weak ammonia or fish-like odor. The odor threshold is 0.01 ppm.
ColorAPHA: ≤15
OdorCharacteristic amine-like odor
FormLiquid
Water SolubilityMISCIBLE
Vapor Pressure31 mm Hg ( 38 °C)
Refractive Indexn 20/D 1.454(lit.)
pH11.2 (H2O)(undiluted)
Log P-0.860

Safety & Handling

Danger
GHS02· FlammableGHS05· CorrosiveGHS07· IrritantGHS09· EnvironmentGHS06· ToxicGHS08· Health Hazard

Hazard Statements

H226Flammable liquid and vapor
H290May be corrosive to metals
H302Harmful if swallowed
H311Toxic in contact with skin
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H319Causes serious eye irritation
H331Toxic if inhaled
H332Harmful if inhaled
H341Suspected of causing genetic defects
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
H402Harmful to aquatic life
H411Toxic to aquatic life with long lasting effects H302+H312+
H332Harmful if swallowed, in contact with skin or if inhaled

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P234Keep only in original packaging.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P390Absorb spillage to prevent material damage.
P391Collect spillage.
P405Store locked up.
P406Store in a corrosion-resistant/… container with a resistant inner liner.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off immediately all contaminated clothing and wash it before reuse.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P233Store in a well-ventilated place. Keep container tightly closed.
P235Store in a well-ventilated place. Keep cool.
P331Rinse mouth. Do NOT induce vomiting.
P354IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29349900
UN Number2054
ADR Class8
Packing GroupI
Storage Class3 - Flammable liquids
WGK (Germany)3