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6-hydroxybenzomorpholine

CAS Number
26021-57-8
EC Number
247-415-5
Chemical Formula
C8H9NO2
Molecular Weight
151.16 g/mol

Description

6-Hydroxybenzomorpholine (CAS 26021-57-8 ), also referenced as 3,4-Dihydro-2H-1,4-benzoxazin-6-ol, is a hydroxyl-functionalized benzoxazine heterocycle used as a building block. It is utilized in pharmaceutical synthesis and specialty chemical manufacturing. Its reactive phenolic hydroxyl group makes it a sought-after intermediate for constructing complex molecular architectures. In pharmaceutical synthesis, this compound serves as a key intermediate for active pharmaceutical ingredient development. Its benzoxazine scaffold supports the construction of targeted small-molecule candidates. The compound's hydroxyl functionality enables conjugation and derivatization steps critical to medicinal chemistry workflows. It is essential for researchers working on drug development pipelines. In polymer chemistry, it functions as a polymerization initiator, particularly in ring-opening systems where controlled initiation is required. This allows for precise chemical engineering. Biotechnology researchers also employ it in the preparation of probe molecules and ligand scaffolds for receptor binding studies. This versatility makes it a valuable asset in various labs. The material is supplied as a solid powder, typically at high purity levels suited to research and intermediate-scale synthesis. It is available in research quantities through to kilogram lots. Specifications are generally aligned with pharmaceutical intermediate standards. Documentation provided includes a COA, HPLC purity data, and NMR confirmation to ensure chemical integrity. Contact us for supply of 6-hydroxybenzomorpholine Request Quote

Other Names (Synonyms)

3,4-Dihydro-2H-1,4-benzoxazin-6-ol | 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- | 77OXT3492A | 3,4-DIHYDRO-2H-BENZO-(B)(1,4)OXAZIN-6-OL | 3,4-DIHYDRO-6-HYDROXY-1,4(2H)-BENZOXAZINE | 6-Hydroxyphenomorpholine

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Boiling Point334.7±42.0 °C(Predicted)
Density1.241±0.06 g/cm3(Predicted)
ColorBlack
FormSolid
Water Solubility19g/L@20°C
Vapor Pressure0.002Pa@20°C
Log P0.219 at 23℃

Safety & Handling

Warning
GHS07· IrritantGHS09· Environment

Hazard Statements

H302Harmful if swallowed
H319Causes serious eye irritation
H411Toxic to aquatic life with long lasting effects

Precautionary Statements

P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P330Rinse mouth.
P391Collect spillage.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code2934999090