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Chloroacetyl chloride

CAS Number
79-04-9
EC Number
201-171-6
Chemical Formula
C2H2Cl2O
Molecular Weight
112.94 g/mol

Description

Chloroacetyl chloride (CAS 79-04-9 ), also known as CAC, is a highly reactive acylating agent used as a key building block in the synthesis of active pharmaceutical ingredients and agrochemical compounds. Its reactivity toward amines, alcohols, and other nucleophiles makes it a preferred reagent for introducing the chloroacetyl group in multi-step synthesis programs for various industrial applications. In pharmaceutical manufacturing, CAC is used to synthesize a range of APIs including local anesthetics, cardiovascular drugs, and CNS compounds where the chloroacetyl moiety is a critical structural feature. Agrochemical producers rely on it as an intermediate in the production of herbicides and fungicides, particularly chloroacetamide-class herbicides used in crop protection formulations for global agriculture. In biotechnology and life sciences, it serves in the preparation of reactive intermediates and labeling reagents used in research-scale synthesis and specialized laboratory applications across the sector. Industrial chemical manufacturers also use CAC to produce thioethers and other specialty compounds through nucleophilic substitution reactions, ensuring high yields and consistent chemical performance. Chloroacetyl chloride is supplied as a liquid, typically in drums or ISO containers suited to its corrosive and moisture-sensitive handling requirements for safe transport and storage. It is available in technical and synthesis-grade specifications, with purity levels commonly at 98% or higher for industrial and pharmaceutical intermediate use in high-demand manufacturing environments. Contact us for supply of Chloroacetyl chloride Request Quote

Other Names (Synonyms)

Monochloroacetyl chloride | Chloroacetic chloride | Chloroacetic acid chloride | 2-chloroacetyl chloride | Acetyl chloride, chloro- | Chloracetyl chloride | Chlorure de chloracetyle | Chlorid kyseliny chloroctove | CAC

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-21.77 °C
Boiling Point106 °C
Density1.4202 g/cm³ @ Temp: 20 °C
Flash Point>100°C
AppearanceChloroacetyl chloride is a colorless to yellowish liquid with a very pungent, extremely irritating, odor.
ColorClear colorless to slightly yellow
Odorstrong pungent odor
FormLiquid
Water Solubilityreacts
Vapor Pressure60 mm Hg ( 41.5 °C)
Refractive Indexn 20/D 1.453(lit.)

Safety & Handling

Danger
GHS05· CorrosiveGHS06· ToxicGHS08· Health HazardGHS09· EnvironmentGHS07· Irritant

Hazard Statements

H290
H290
H301
H301
H310
H310
H311
H311
H314
H314
H315
H315
H318
H318
H319
H319
H330
H330
H331
H331
H370
H370
H372
H372
H400
H400
H410H410

Precautionary Statements

P234
P234
P260
P260
P261
P261
P262
P262
P264
P264
P270
P270
P271
P271
P273
P273
P280
P280
P284
P284
P316
P316
P317
P317
P319
P319
P320
P320
P321
P321
P330
P330
P363
P363
P390
P390
P391
P391
P405
P405
P406
P406
P501
P501
P265
P265
P316
P316
P352
P352
P340
P340
P316
P316
P317
P317
P317
P317
P364
P364
P364
P364
P233
P233
P331
P331
P354
P354
P338
P338
P338

Trade & Regulatory

HS Code29159000
UN Number1752
ADR Class6.1
Packing GroupI
Storage Class6.1A - Combustible, acute toxic Cat. 1 and 2 very toxic hazardous materials
WGK (Germany)3