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4-chlorobutanoic acid

CAS Number
627-00-9
EC Number
210-975-2
Chemical Formula
C4H7ClO2
Molecular Weight
122.55 g/mol

Description

4-Chlorobutanoic acid (CAS 627-00-9 ), also known as 4-chlorobutyric acid and gammachlorobutyric acid, is a halogenated organic acid used primarily as a building block in pharmaceutical synthesis. Its reactive chloro and carboxylic acid groups make it a functional intermediate for constructing more complex active pharmaceutical ingredients and specialty molecules. In pharmaceutical manufacturing, it serves as a key intermediate. This is particularly useful where a four-carbon chain with terminal halogenation is required for cyclization or chain extension reactions. Biotechnology and life sciences researchers use it in the preparation of labeled compounds. It is also utilized for linkers and probe molecules for drug discovery workflows. The compound also supports agrochemical synthesis, where halogenated acid intermediates are used to produce herbicide and pesticide active substances. Its chloro group enables nucleophilic substitution reactions that are central to constructing gamma-lactam and pyrrolidone ring systems. These systems are found in several drug scaffolds across the medical industry. 4-Chlorobutanoic acid is supplied as a liquid or low-melting solid depending on purity and storage conditions. It is available in technical and high-purity grades suited to pharmaceutical intermediate and research applications. Packaging ranges from small quantities for laboratory use to bulk quantities for industrial synthesis programs. This ensures that the product meets the specific requirements of both small-scale labs and large manufacturers. Contact us for supply of 4-chlorobutanoic acid Request Quote

Other Names (Synonyms)

4-chlorobutyric acid | Butanoic acid, 4-chloro- | Gammachlorobutyric acid | Cl(CH2)3COOH | .gamma.-Chloro-n-butyric acid | Butyric acid, 4-chloro- | γ-Chlorobutyric acid | 4-CBA

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point16 °C
Boiling Point67-72 °C @ Press: 2.5 Torr
Density1.2373 g/cm³ @ Temp: 20 °C
Flash Point>230 °F
ColorColorless to Almost colorless
Formclear liquid
Refractive Indexn 20/D 1.451(lit.)

Safety & Handling

Danger
GHS05· CorrosiveGHS07· Irritant

Hazard Statements

H302
H302
H314H314

Precautionary Statements

P260
P260
P264
P264
P270
P270
P280
P280
P316
P316
P321
P321
P330
P330
P363
P363
P405
P405
P501
P501
P317
P317
P340
P340
P331
P331
P354
P354
P338

Trade & Regulatory

HS Code29159000
UN Number3265
ADR Class8
Packing GroupII
Storage Class8A - Combustible corrosive hazardous materials
WGK (Germany)3