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Acetyl chloride

CAS Number
75-36-5
EC Number
200-865-6
Chemical Formula
C2H3ClO
Molecular Weight
78.50 g/mol

Description

Acetyl chloride (CAS 75-36-5 ), also known as acetic chloride, is a highly reactive acylating agent used across pharmaceutical synthesis and specialty chemical manufacturing. It introduces acetyl groups into organic molecules, enabling the construction of active pharmaceutical ingredients and chemical intermediates at scale. In pharmaceutical manufacturing, acetyl chloride acetylates amines, alcohols, and phenols to produce APIs and protected intermediates where precise reaction control is critical. Cosmetic ingredient synthesis relies on it to produce acetylated derivatives. Fatty alcohols and other actives are modified to improve stability or skin-feel performance in finished formulations. It also functions as a catalyst activator and reagent in the preparation of anhydrides and other acylating agents used upstream in fine chemical production. Contract manufacturers and formulators processing complex multi-step syntheses source it as a key reagent where high purity and consistent reactivity directly affect yield. This ensures that the final chemical products meet rigorous industrial requirements. Acetyl chloride is supplied as a colorless fuming liquid, typically in drums or ISO tanks suited for moisture-sensitive materials. Technical and high-purity reagent grades are the standard commercial offerings for industrial applications. Purity specifications are commonly at 98% and above to ensure optimal performance in sensitive reactions. Packaging configurations are selected to maintain anhydrous conditions throughout storage and transport to prevent degradation. Contact us for supply of Acetyl chloride Request Quote

Other Names (Synonyms)

ethanoyl chloride | CH3COCl | acetic chloride | acetic acid chloride | QD15RNO45K

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-112 °C
Boiling Point52 °C
Density1.1051 g/cm³ @ Temp: 20 °C
Flash Point40 °F
AppearanceAcetyl chloride is a highly flammable, colorless, fuming liquid with a pungent odor
ColorClear colorless
OdorStrong pungent odor
FormLiquid
Water SolubilityDecomposes violently in water
Vapor Pressure11.69 psi ( 20 °C)
Refractive Indexn 20/D 1.389(lit.)

Safety & Handling

Danger
GHS02· FlammableGHS05· CorrosiveGHS07· Irritant

Hazard Statements

H225Highly Flammable liquid and vapor
H290May be corrosive to metals
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H335May cause respiratory irritation
H402Harmful to aquatic life

Precautionary Statements

P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P234Keep only in original packaging.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P390Absorb spillage to prevent material damage.
P405Store locked up.
P406Store in a corrosion-resistant/… container with a resistant inner liner.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P378Use … for extinction.
P233Store in a well-ventilated place. Keep container tightly closed.
P235Store in a well-ventilated place. Keep cool.
P331Rinse mouth. Do NOT induce vomiting.
P354IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29159080
UN Number1717
ADR Class3
Packing GroupII
Storage Class3 - Flammable liquids
WGK (Germany)1