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5-chlorosalicylic acid

CAS Number
321-14-2
EC Number
206-283-9
Chemical Formula
C7H5ClO3
Molecular Weight
172.56 g/mol

Description

5-Chlorosalicylic acid (CAS 321-14-2 ), also referenced in procurement as 5-CSA, is an organochlorine derivative of salicylic acid used as a building block in pharmaceutical synthesis and as a functional additive in industrial formulations. Its combination of phenolic and carboxylic acid groups makes it a reactive intermediate for producing active pharmaceutical ingredients and specialty performance chemicals. In pharmaceutical manufacturing, 5-CSA serves as a key intermediate. It is used in the synthesis of antimicrobial and anti-inflammatory APIs, where controlled chlorination and hydroxyl positioning are critical to the final molecule's activity. Coating and resin formulators incorporate it as a UV stabilizer. It also acts as an antioxidant to extend the service life of protective coatings exposed to outdoor weathering. In adhesive and sealant systems, it contributes biocidal and preservation properties that inhibit microbial degradation. These properties help maintain the product's shelf life. Personal care formulators also evaluate it as a preservative-boosting component in leave-on and rinse-off products where broad-spectrum efficacy is required. 5-Chlorosalicylic acid is supplied as a white to off-white crystalline powder. Technical and pharmaceutical-grade material is available, with pharmaceutical-grade product typically meeting defined purity thresholds. This grade is suitable for API intermediate use. Packaging ranges from kilogram-scale laboratory quantities to bulk drum supply for industrial procurement, ensuring flexibility for various manufacturing scales and requirements. Contact us for supply of 5-chlorosalicylic acid Request Quote

Other Names (Synonyms)

5-Chloro-2-hydroxybenzoic acid | 5 CSA | 2-Hydroxy-5-chlorobenzoic acid | Benzoic acid, 5-chloro-2-hydroxy- | Salicylic acid, 5-chloro- | J2YFG68VCZ

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point171.5 °C
Boiling Point244.67°C (rough estimate)
Density1.3766 (rough estimate)
AppearanceOFF-WHITE TO CREAM POWDER
ColorWhite to Almost white
Formpowder to crystal
Water Solubility1 g/L (20 ºC)
Refractive Index1.4580 (estimate)
pH2.5 (H2O, 20℃)(aqueous suspension)
Log P3.090

Safety & Handling

Danger
GHS06· ToxicGHS07· Irritant

Hazard Statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P316Get emergency medical help immediately.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29182990
UN Number2811
ADR Class6.1
Packing GroupIII
Storage Class6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany)3