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2-chloro-5-methoxyaniline

CAS Number
2401-24-3
EC Number
219-277-6
Chemical Formula
C7H8ClNO
Molecular Weight
157.60 g/mol

Description

2-Chloro-5-methoxyaniline (CAS 2401-24-3 ), also known commercially as 6-chloro-m-anisidine, is an aromatic amine intermediate used in the synthesis of active pharmaceutical ingredients and specialty agrochemicals. Its dual functional groups, a reactive amine and a chloro substituent, make it a building block for constructing complex heterocyclic and azo-based target molecules for various industrial applications. In pharmaceutical synthesis, it serves as a key starting material for manufacturing drug candidates, particularly in programs targeting kinase inhibitors and other small-molecule therapeutics where precise substitution patterns are required. Agrochemical manufacturers use it in the production of herbicide and fungicide active ingredients, where the chloro and methoxy groups direct selective reactivity during coupling steps in the manufacturing process. Dye and pigment producers incorporate it into azo dye synthesis, where the aniline nitrogen undergoes diazotization to generate stable colorant intermediates for textile and industrial coatings. It also appears in polymer research as a co-monomer or initiator component in specialty polymerization systems. This versatile chemical is typically supplied as a liquid or low-melting solid for easy handling. It is available in technical grade for industrial synthesis and in higher-purity grades suited to pharmaceutical intermediate applications. Packaging ranges from small research quantities to bulk drum supply. Contact us for supply of 2-chloro-5-methoxyaniline Request Quote

Other Names (Synonyms)

6-Chloro-m-anisidine | Benzenamine, 2-chloro-5-methoxy- | 8UQ785S8U6 | 2-CHLORO-5-METHOXYBENZENAMINE | RefChem:541851 | m-Anisidine, 6-chloro- | 3-Amino-4-chloroanisole

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point27 °C
Boiling Point136-137 °C @ Press: 10 Torr
Density1.261 g/mL at 25 °C
Flash Point135-137°C/12mm
ColorWhite or Colorless to Yellow to Orange
Formpowder to lump to clear liquid
Water SolubilitySlightly soluble in water.
Refractive Index1.5848

Safety & Handling

Danger
GHS06· ToxicGHS07· IrritantGHS08· Health Hazard

Hazard Statements

H301Toxic if swallowed
H302Harmful if swallowed
H311Toxic in contact with skin
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off immediately all contaminated clothing and wash it before reuse.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code2922290090
Storage Class13 - Non Combustible Solids
WGK (Germany)3