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2-amino-5-chlorobenzotrifluoride

CAS Number
445-03-4
EC Number
207-151-3
Chemical Formula
C7H5ClF3N
Molecular Weight
195.57 g/mol

Description

2-Amino-5-chlorobenzotrifluoride (CAS 445-03-4 ), also known as 2-Trifluoromethyl-4-chloroaniline, is an aromatic amine intermediate built around a trifluoromethyl group and a reactive primary amine. It serves as a key building block in the synthesis of active pharmaceutical ingredients, agrochemicals, and specialty dyes. In pharmaceutical manufacturing, it is used to construct drug candidates and APIs. The trifluoromethyl group is required to improve metabolic stability and membrane permeability. Dye and pigment producers use it as a coupling component or precursor in the synthesis of azo colorants. These colorants are used for textile and paper applications. Its biocidal profile supports use in formulations targeting preservation applications within personal care and cosmetic products. The compound also appears in agrochemical synthesis, where fluorinated aniline scaffolds are used to build herbicide and fungicide active substances. It is supplied as a liquid or low-melting solid. This depends on purity and handling conditions. It is available in technical and high-purity grades suited to pharmaceutical intermediate and fine chemical manufacturing requirements. Packaging options typically range from small laboratory quantities through to bulk drums for industrial-scale procurement. This ensures flexibility for various production scales and research needs. Contact us for supply of 2-amino-5-chlorobenzotrifluoride Request Quote

Other Names (Synonyms)

4-Chloro-alpha,alpha,alpha-trifluoro-o-toluidine | Benzenamine, 4-chloro-2-(trifluoromethyl)- | 2-Trifluoromethyl-4-chloroaniline | RefChem:561881 | 4-Chloro-2-(trifluoromethyl)aniline | o-Toluidine, 4-chloro-α,α,α-trifluoro- | 4-Chloro-2-(trifluoromethyl)benzenamine | C.I. 37055

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point8.8 °C
Boiling Point76-78 °C @ Press: 4-5 Torr
Density1.386 g/mL at 25 °C(lit.)
Flash Point203 °F
AppearanceClear yellow liquid
ColorColorless to Orange to Green
Formclear liquid
Vapor Pressure48.5-1013hPa at 110.5-208.2℃
Refractive Indexn 20/D 1.507(lit.)
pH7.4 at 20℃ and 995mg/L
Log P2.68

Safety & Handling

Warning
GHS07· IrritantGHS08· Health Hazard

Hazard Statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H373May causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P317Get emergency medical help.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29214300
UN Number2810
Storage Class10 - Combustible liquids
WGK (Germany)2