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Lisinopril dihydrate

CAS Number
83915-83-7
EC Number
627-033-9
Chemical Formula
C21H31N3O5.2H2O
Molecular Weight
441.5 g/mol

Description

Lisinopril dihydrate (CAS 83915-83-7 ) is the stable, hydrated crystalline form of lisinopril, a lysine-proline derivative used as an active pharmaceutical ingredient in antihypertensive drug manufacturing. Its dihydrate form is the commercially preferred specification for finished dosage form production, offering consistent physical stability under standard storage conditions for global distribution. The primary application is in the manufacture of oral solid dosage forms, such as tablets and capsules, targeting hypertension and heart failure treatment where it functions as the API in formulations. Contract manufacturers and generic drug producers source it as a pharmaceutical intermediate for direct compression or wet granulation processes. It is a staple in modern cardiovascular medicine production. Formulators working on combination antihypertensive products incorporate it alongside diuretics such as hydrochlorothiazide in fixed-dose tablet formats to improve patient compliance and therapeutic outcomes. Reference standard quantities are also procured by QA laboratories and analytical teams for method validation and release testing. This ensures the highest level of safety and efficacy in the final product. Lisinopril dihydrate is supplied as a white to off-white crystalline powder. It is available in pharmaceutical-grade specifications meeting USP , BP , and Ph. Eur. compendial standards. These are the primary requirements for API procurement in regulated markets. Packaging is typically offered in small quantities for laboratory use through to bulk quantities for commercial manufacturing. Contact us for supply of Lisinopril dihydrate Request Quote

Other Names (Synonyms)

LISINOPRIL DIHYDRATE [MI] | LISINOPRIL DIHYDRATE [WHO-DD] | N(2)-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline dihydrate | (S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate | RefChem:799369 | L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2) | L-Proline, 1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-, dihydrate, (S)-

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point148 °C
AppearanceWhite to Off-White Crystalline Powder
Colorwhite
Formsolid
Water SolubilityH2O: ≥10mg/mL DMSO: ~6.5mg/mL (with heating and sonicating)
Refractive Index-45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)

Safety & Handling

Danger
GHS08· Health Hazard

Hazard Statements

H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.

Trade & Regulatory

HS Code2933995300
Storage Class6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany)3