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Losartan potassium

CAS Number
124750-99-8
EC Number
627-032-3
Chemical Formula
C22H23ClN6O.K
Molecular Weight
461.0 g/mol

Description

Losartan potassium (CAS 124750-99-8 ) is an angiotensin II receptor antagonist active pharmaceutical ingredient used in the manufacture of antihypertensive drug products. Known under the reference brand Cozaar, it is a finished API supplied to generic drug manufacturers. Generic pharmaceutical manufacturers use this material as the primary API in solid oral dosage forms, including tablets and film-coated tablets targeting hypertension and diabetic nephropathy indications. It is essential for cardiovascular therapies. Contract development organizations source it for bioequivalence study batches and formulation development against the reference listed drug. It is also procured by compounding pharmacies requiring a documented API for patient-specific preparations. Combination product developers incorporate it alongside diuretics such as hydrochlorothiazide in fixed-dose formulation programs. This versatility makes it a staple in modern pharmaceutical manufacturing and drug development cycles. The material is supplied as a white to off-white crystalline powder. It is available in USP and EP ( Ph.Eur. ) grades, with ICH-compliant documentation packages including full DMF or ASMF references. Regulated market buyers typically require these high-quality standards for their supply chains. Quantities range from research-scale to multi-kilogram commercial batches to meet various production needs. GMP-certified manufacture is expected for finished dosage form supply chains to ensure safety and efficacy. This ensures that the final pharmaceutical products meet all necessary regulatory requirements for global distribution. Contact us for supply of Losartan potassium Request Quote

Other Names (Synonyms)

Cozaar | Losacar | Losaprex | Losata | Tancin | Nu-Lotan | Aradois | Zaart

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point183.5-184.5 °C
AppearanceWhite to Off-White Crystalline Powder
ColorOff-white
Formpowder or crystals
Water SolubilityH2O: 2mg/mL, clear

Safety & Handling

Danger
GHS05· CorrosiveGHS07· IrritantGHS08· Health Hazard

Hazard Statements

H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
H319Causes serious eye irritation
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
H373May causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy and while nursing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code2933290000
WGK (Germany)3