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Valsartan

CAS Number
137862-53-4
EC Number
604-045-2
Chemical Formula
C24H29N5O3
Molecular Weight
435.5 g/mol

Description

Valsartan (CAS 137862-53-4 ), also known as VAL489, is an angiotensin II receptor antagonist used as an active pharmaceutical ingredient in the treatment of hypertension and heart failure. It functions by selectively blocking the AT1 receptor subtype. This makes it a core API in cardiovascular drug formulations worldwide. Valsartan is the primary active ingredient in oral solid dosage forms, such as tablets and capsules, manufactured for antihypertensive therapy. It is often utilized in combination products alongside hydrochlorothiazide or amlodipine. Pharmaceutical manufacturers source it as a key API for generic drug production, where it undergoes formulation development and bioequivalence testing. The material is also essential for regulatory filing and clinical trials. Contract research organizations and formulation labs procure it for analytical reference standards and method development work to ensure product quality. In some specialty contexts, it is evaluated within peptide-adjacent research programs targeting cardiovascular peptide pathways. Valsartan is supplied as a white to off-white crystalline powder for industrial use. It is available in pharmaceutical-grade specifications conforming to USP , Ph.Eur. ( EP ), and BP monographs, supporting GMP-compliant manufacturing processes across various global regions. Quantities range from research-scale lots to multi-kilogram commercial batches. Documentation packages including CoA, DMF references, and impurity profiles are available on request to support your compliance needs. Contact us for supply of Valsartan Request Quote

Other Names (Synonyms)

VAL489 | N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine | N-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine | (S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine | Diovan | 80M03YXJ7I

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point116-117 °C
Boiling Point684.9±65.0 °C(Predicted)
Density1.286 g/cm³
AppearanceWhite Crystalline Powder
Colorwhite to tan
Formpowder
Water Solubility84.99mg/L(25 ºC)
Vapor Pressure0-0Pa at 20-25℃
Log P1.2-2.8 at 25℃ and pH2.5-7

Safety & Handling

Warning
GHS08· Health Hazard

Hazard Statements

H361Suspected of damaging fertility or the unborn child
H412Harmful to aquatic life with long lasting effects

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P318IF exposed or concerned, get medical advice.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.

Trade & Regulatory

HS Code29339900
Storage Class11 - Combustible Solids
WGK (Germany)3