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Pharmaceutical Intermediates REACH

Memantine hydrochloride

CAS Number
41100-52-1
EC Number
255-219-6
Chemical Formula
C12H21N.ClH
Molecular Weight
215.76 g/mol
Industries:Pharmaceuticals & Healthcare

Description

Memantine hydrochloride (CAS 41100-52-1 ) is the salt form of memantine, an NMDA receptor antagonist active pharmaceutical ingredient used in the treatment of moderate-to-severe Alzheimer's disease. Supplied as a finished API or pharmaceutical intermediate, it is a primary target for generic drug manufacturers and contract formulators sourcing for solid oral dosage development. Generic pharmaceutical manufacturers use this material as the active ingredient in immediate-release and extended-release tablet formulations indicated for cognitive decline disorders. Contract development organizations source it as a reference standard or bulk API for bioequivalence studies and formulation development against branded products in the marketplace. It is also procured by compounding pharmacies requiring a documented API for patient-specific preparations. Research institutions source pharmaceutical-grade material for investigational use. Memantine hydrochloride is available as a white crystalline powder in bulk quantities ranging from laboratory-scale to commercial API lots for global distribution and manufacturing. Standard supply grades include USP , EP ( Ph. Eur. ), and in-house pharmaceutical grades with full ICH-compliant documentation packages for regulatory submission. Certificates of Analysis, DMF references, and impurity profiles are standard documentation expectations for this material in regulated markets to ensure safety and compliance. Contact us for supply of Memantine hydrochloride Request Quote

Other Names (Synonyms)

memantine.HCl | 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine hydrochloride | 3,5-dimethyladamantan-1-aminium chloride | 3,5-Dimethyl-1-adamantanamine hydrochloride | 1-Amino-3,5-dimethyladamantane hydrochloride | 3,5-dimethyladamantan-1-amine hydrochloride | Akatinol | Namenda XR

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point290-295 °C
AppearanceCrystalline Solid
ColorWhite
FormFine Powder
Water SolubilitySoluble in water (100mM)

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H336May cause drowsiness or dizziness

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P317Get emergency medical help.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29213000
Storage Class11 - Combustible Solids
WGK (Germany)3