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Histidine monohydrochloride monohydrate

CAS Number
5934-29-2
EC Number
611-821-4
Chemical Formula
C6H9N3O2.ClH.H2O
Molecular Weight
209.63 g/mol

Description

Histidine monohydrochloride monohydrate (CAS 5934-29-2 ), also supplied as L-histidine hydrochloride, is the stabilized salt form of the essential amino acid L-histidine. Its hydrated, water-soluble structure makes it the preferred form for buffering and stabilizing sensitive formulations. This compound is essential for buffering across pharmaceutical, nutritional, and cosmetic manufacturing. In biopharmaceutical manufacturing, it functions as a primary buffer component in monoclonal antibody and protein drug formulations. Precise pH control directly impacts product stability and shelf life in these applications. Parenteral and injectable drug products rely on this grade to maintain formulation integrity during freeze-drying and long-term storage. In food and nutritional supplement production, it is used as an amino acid fortifier in clinical nutrition products. It is also a key ingredient in infant formula and sports nutrition blends to ensure proper amino acid profiles. Cosmetic formulators incorporate it into skin care products for its moisture-retention and antioxidant-stabilizing properties. It is particularly effective in serums and treatment creams targeting sensitive skin types. Histidine monohydrochloride monohydrate is available as a white crystalline powder. It is commonly supplied in USP , BP , and Ph. Eur. grades to meet pharmaceutical manufacturing requirements. Food-grade specifications are also available for nutritional applications. Bulk quantities are typically offered in fiber drums or double-lined polyethylene bags to ensure product safety and stability during transport. Contact us for supply of Histidine monohydrochloride monohydrate Request Quote

Other Names (Synonyms)

L-histidine hydrochloride | L-histidine monohydrochloride monohydrate | (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid;hydrate;hydrochloride | L-histidine hydrochloride monohydrate

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point254 °C (decomp)
Density1.49 g/cm3
AppearanceWhite crystals or crystalline powder
ColorWhite
Odorodorless
FormSolid
Water Solubility169.9 g/L (20 ºC)
Vapor Pressure<1 hPa (20 °C)
pH3.5-4.5 (100g/l, H2O, 20℃)
Log P-3.32 at 25℃

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H315Causes skin irritation
H319Causes serious eye irritation

Precautionary Statements

P264Wash … thoroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P321Specific treatment (see … on this label).
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29332990
WGK (Germany)3