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Acetonitrile

CAS Number
75-05-8
EC Number
200-835-2
Chemical Formula
C2H3N
Molecular Weight
41.05 g/mol

Description

Acetonitrile (CAS 75-05-8 ), also known commercially as ACN or methyl cyanide, is a high-purity polar aprotic solvent used across pharmaceutical manufacturing, analytical chemistry, and industrial synthesis. Its low viscosity and miscibility with water make it the dominant solvent choice in HPLC and LC-MS workflows globally. In pharmaceutical manufacturing, ACN serves as a reaction solvent and purification medium. It is used for active pharmaceutical ingredients, particularly in peptide synthesis and chromatographic separation at scale. Life science and biotech laboratories rely on it as the primary mobile phase solvent. In reversed-phase HPLC, consistent purity directly impacts analytical reproducibility and regulatory compliance. Agrochemical producers use ACN as a solvent in the synthesis and formulation of pesticide intermediates. Its solvating power supports high-yield reaction conditions. In printing and packaging, it functions as a solvent carrier in specialty ink and dye formulations requiring fast evaporation and clean substrate adhesion. Acetonitrile is supplied as a clear liquid in drums, IBCs, and bulk tanker quantities. HPLC-grade and LC-MS-grade are the most commercially demanded specifications for high-end laboratory use. Technical-grade is available for industrial synthesis applications. Gradient-grade variants meeting stringent UV absorbance cutoffs are standard for analytical supply channels and quality control. Contact us for supply of Acetonitrile Request Quote

Other Names (Synonyms)

methyl cyanide | ethyl nitrile | ACN | Methane, cyano- | Cyanure de methyl | Cyanomethane.

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-45 °C
Boiling Point81.6 °C @ Press: 760 Torr
Density0.78745 g/cm³ @ Temp: 15 °C
Flash Point48 °F
AppearanceAcetonitrile is an extremely flammable, colorless liquid with an ethereal odor
Color<10(APHA)
OdorAromatic ether-like odor detectable at 40 ppm
Formliquid
Water Solubilitymiscible
Vapor Pressure72.8 mm Hg ( 20 °C)
Refractive Indexn 20/D 1.344(lit.)
Log P-0.340

Safety & Handling

Danger
GHS02· FlammableGHS07· IrritantGHS06· ToxicGHS08· Health HazardGHS05· Corrosive

Hazard Statements

H225Highly Flammable liquid and vapor
H302Harmful if swallowed
H303May be harmful if swallowed
H311Toxic in contact with skin
H312Harmful in contact with skin
H318Causes serious eye damage
H319Causes serious eye irritation
H332Harmful if inhaled
H341Suspected of causing genetic defects
H370Causes damage to organs
H373May causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off immediately all contaminated clothing and wash it before reuse.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P235Store in a well-ventilated place. Keep cool.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29269095
UN Number1993
ADR Class3
Packing GroupIII
WGK (Germany)2