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Amines REACH

Dimethylacetamide

CAS Number
127-19-5
EC Number
204-826-4
Chemical Formula
C4H9NO
Molecular Weight
87.12 g/mol

Description

Dimethylacetamide ( CAS 127-19-5 ), commonly known as DMAc or DMAC, is a high-boiling polar aprotic solvent used across pharmaceutical manufacturing, fiber production, and specialty chemical processing. Its strong solvating power makes it the preferred choice for dissolving polymers, active pharmaceutical ingredients, and resins that resist conventional solvents. In pharmaceutical manufacturing, DMAc is used as a reaction solvent. It serves as a crystallization medium for APIs, particularly in the synthesis of antibiotics and oncology compounds where solubility and process consistency are critical. Fiber and membrane producers rely on it to dissolve polyacrylonitrile. It is also used for aramid polymers for wet-spinning processes, including the production of carbon fiber precursors and filtration membranes. It functions as a process solvent in the manufacture of polyurethane films and coatings. This enables uniform dispersion of high-molecular-weight resins. In agrochemical and specialty chemical synthesis, DMAc supports reactions requiring a stable, high-boiling medium that remains inert under demanding conditions. DMAc is supplied as a clear liquid in drums, IBCs, and bulk tanker quantities. Standard commercial grades include technical grade and pharmaceutical-grade specifications for industrial use. The material is compliant with various regulatory standards and is often categorized as an ICH Q3C Class 2 solvent. Moisture content and purity levels are typically specified to meet the requirements of regulated environments. These specifications ensure the product meets the necessary criteria for high-stakes manufacturing. Quality control measures are strictly followed to maintain the integrity of the solvent during transport and storage. Contact us for supply of Dimethylacetamide Request Quote

Other Names (Synonyms)

N,N-Dimethyl acetamide | DMAC | Acetamide, N,N-dimethyl- | Dimethylamide acetate | N,N-Dimethylethanamide

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-18.59 °C
Boiling Point163-165 °C
Density0.9366 g/cm³ @ Temp: 25 °C
Flash Point158 °F
Appearancecolourless liquid with a faint ammonia odour
ColorColorless to yellowish
OdorFaint ammonia odor
FormLiquid
Water Solubilitymiscible
Vapor Pressure40 mm Hg ( 19.4 °C)
Refractive Indexn 20/D 1.439(lit.)
pH4 (200g/l, H2O, 20℃)
Log P-0.77 at 25℃

Safety & Handling

Danger
GHS07· IrritantGHS08· Health HazardGHS06· Toxic

Hazard Statements

H227Combustible liquid
H303May be harmful if swallowed
H312Harmful in contact with skin
H313May be harmful in contact with skin
H316Causes mild skin irritation
H319Causes serious eye irritation
H320Causes eye irritation
H331Toxic if inhaled
H332Harmful if inhaled
H336May cause drowsiness or dizziness
H350May cause cancer
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
H373May causes damage to organs through prolonged or repeated exposure H312+
H332Harmful in contact with skin or if inhaled

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P403Store in a well-ventilated place.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29241900
Storage Class6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany)2