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2,2-dimethoxypropane

CAS Number
77-76-9
EC Number
201-056-0
Chemical Formula
C5H12O2
Molecular Weight
104.15 g/mol

Description

2,2-Dimethoxypropane (CAS 77-76-9 ), commonly known as DMP or acetone dimethyl acetal, is a reactive solvent and dehydrating agent used across pharmaceutical, biotech, and specialty chemical manufacturing. It functions primarily as a water scavenger and protecting group reagent, enabling moisture-sensitive reactions and synthesis steps that require controlled anhydrous conditions. In pharmaceutical synthesis, DMP protects carbonyl and hydroxyl groups during multi-step API manufacturing, reducing side reactions and improving yield consistency for manufacturers. Biotech and life sciences laboratories use it as a rapid chemical dehydrant for biological sample preparation, particularly in electron microscopy tissue processing where water removal must be precise. As a flavoring intermediate, acetone dimethyl acetal contributes to the production of certain aroma compounds where controlled acetal chemistry is required for the final product. It also functions as a solvent in reactions where conventional polar aprotic solvents are unsuitable due to moisture sensitivity. This makes it a versatile tool in complex chemical synthesis. 2,2-Dimethoxypropane is supplied as a clear liquid in standard drum and IBC quantities, with bulk availability for industrial-scale procurement. Technical grade is the most common commercial specification. High-purity grades are available to meet pharmaceutical and analytical laboratory requirements. Buyers should confirm purity thresholds and water content specifications with suppliers as a critical quality parameter. Contact us for supply of 2,2-dimethoxypropane Request Quote

Other Names (Synonyms)

Acetone dimethyl acetal | Propane, 2,2-dimethoxy- | Acetone dimethyl ketal | 66P41R0030 | RefChem:81029 | DMP

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-47 °C
Boiling Point83 °C
Density0.86199 g/cm³ (solid) @ Temp: 90 °C
Press750 Torr
Flash Point12 °F
Appearancecolourless liquid
ColorClear colorless
FormLiquid
Water Solubility18 g/100 mL (25 ºC)
Vapor Pressure60 mm Hg ( 15.8 °C)
Refractive Indexn 20/D 1.378(lit.)

Safety & Handling

Danger
GHS02· FlammableGHS07· Irritant

Hazard Statements

H225Highly Flammable liquid and vapor
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary Statements

P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P233Store in a well-ventilated place. Keep container tightly closed.
P235Store in a well-ventilated place. Keep cool.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29110000
UN Number1993
ADR Class3
Packing GroupII
Storage Class3 - Flammable liquids
WGK (Germany)2