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Triphenylphosphine

CAS Number
603-35-0
EC Number
210-036-0
Chemical Formula
C18H15P
Molecular Weight
262.3 g/mol

Description

Triphenylphosphine (CAS 603-35-0 ), commonly abbreviated as TPP, is a phosphorus-based ligand and reagent used across pharmaceutical synthesis, polymer stabilization, and specialty chemical manufacturing. It functions primarily as a catalyst component, reducing agent, and stabilizer precursor in demanding industrial processes. In pharmaceutical manufacturing, TPP is a key reagent in Mitsunobu and Wittig reactions. This material enables stereoselective synthesis of active pharmaceutical ingredients at scale. Polymer producers incorporate it as a processing stabilizer and catalyst precursor in polyester and polyurethane systems. In these applications, it controls oxidative degradation during high-temperature compounding. Printing ink and packaging formulators use TPP-derived systems as photoinitiator components and stabilizers. These additives extend the service life of UV-curable coatings. In specialty catalyst systems, it acts as a ligand for palladium, rhodium, and other transition metals, supporting cross-coupling reactions. Such reactions are critical to fine chemical production. Triphenylphosphine is supplied as a white crystalline powder and is available in technical grade for industrial catalyst and polymer applications. It is also offered in high-purity grades meeting pharmaceutical manufacturing requirements. Packaging options typically range from kilogram-scale bags to bulk drum quantities to suit various needs. These formats support both R&D and production-scale procurement. Our logistics network ensures reliable delivery of this essential phosphorus-based reagent for your specific industrial requirements. Contact us for supply of Triphenylphosphine Request Quote

Other Names (Synonyms)

Phosphine, triphenyl- | PP 360 | TPP

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point80.5 °C
Boiling Point>360 °C
Density1.075 g/cm³ @ Temp: 80 °C
Flash Point181 °C
AppearanceWhite, crystalline solid. Insoluble inwater
slightly soluble in alcohol
soluble in benzene, acetone, carbon tetrachloride. Combustible.
ColorWhite
Odorodorless
FormCrystals, Crystalline Powder or Flakes
Water SolubilityInsoluble
Vapor Pressure5 mm Hg ( 20 °C)
Refractive Index1.6358

Safety & Handling

Danger
GHS05· CorrosiveGHS07· IrritantGHS08· Health Hazard

Hazard Statements

H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
H350May cause cancer
H372Causes damage to organs through prolonged or repeated exposure
H373May causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
H413May cause long lasting harmful effects to aquatic life

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29310095
Storage Class6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany)2