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Thiamin Diphosphate

CAS Number
154-87-0
EC Number
205-230-7
Chemical Formula
C12H19N4O7P2S.Cl
Molecular Weight
460.77 g/mol

Description

Thiamin Diphosphate (CAS 154-87-0 ), also known as Cocarboxylase and abbreviated as TPP, is the biologically active coenzyme form of Vitamin B1. Unlike standard thiamine salts, it is supplied in its phosphorylated form. This makes it the preferred starting material for enzyme-dependent biochemical applications where the coenzyme must be present in ready-to-use form. In pharmaceutical and nutraceutical manufacturing, TPP is used as an active ingredient. It is commonly found in injectable formulations and specialty supplements targeting metabolic support indications. Biotechnology and life sciences buyers source it as a cofactor in enzymatic assay systems and cell culture media. It is also utilized in in vitro diagnostic reagents where direct coenzyme activity is required. Cosmetic formulators incorporate it into skin-conditioning preparations where the phosphorylated B1 form is preferred for bioavailability. The material also functions as a reference standard and process reagent in enzyme kinetics research and fermentation process development. Thiamin Diphosphate is supplied as a crystalline powder, typically as the chloride salt form. Standard grades include pharmaceutical-grade material meeting USP and Ph. Eur. specifications. We also provide research-grade material for laboratory and biotechnology use to meet diverse industrial needs. Bulk quantities are available for industrial pharmaceutical production alongside smaller pack sizes for laboratory procurement. This ensures a reliable supply chain for both large-scale manufacturing and specialized research projects. Contact us for supply of Thiamin Diphosphate Request Quote

Other Names (Synonyms)

Cocarboxylase (inn:dcf:jan) | Vitamin B1 pyrophosphate | 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl phosphono hydrogen phosphate chloride | Thiamine pyrophosphate | Thiamine pyrophosphate chloride | TPP

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point240-244 °C (decomp)
ColorWhite to Off-White
Formneat
Water SolubilityIt is soluble in water.
pH1.0-1.4 (20°C, 100g/L in H2O)

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H317H317

Precautionary Statements

P261
P261
P272
P272
P280
P280
P321
P321
P501
P501
P352
P352
P317
P317
P364

Trade & Regulatory

HS Code29362200
Storage Class11 - Combustible Solids
WGK (Germany)3