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Amines REACH

Tetrabutylurea

CAS Number
4559-86-8
EC Number
224-929-8
Chemical Formula
C17H36N2O
Molecular Weight
284.5 g/mol

Description

Tetrabutylurea (CAS 4559-86-8 ), commonly abbreviated as TBU, is a high-boiling polar aprotic solvent used across pharmaceutical, biotechnology, and industrial cleaning applications. It functions as a carrier and reaction medium where conventional solvents fall short in terms of thermal stability or solvating power. In pharmaceutical synthesis, TBU serves as a process solvent. It is ideal for reactions requiring elevated temperatures and chemical inertness toward sensitive intermediates. Biotechnology workflows use it as a solubilizing carrier for difficult-to-dissolve compounds. Industrial and institutional cleaning formulations incorporate TBU to dissolve stubborn organic residues and polymer deposits. These residues often resist standard solvent systems used in the industry. Its high boiling point also makes it suitable for use in high-temperature coating and specialty chemical processes. Solvent retention and stability are critical procurement considerations for these uses. Tetrabutylurea is supplied as a clear liquid in standard drum and IBC packaging suited for industrial volumes. It is available primarily in technical and high-purity grades for various needs. Purity specifications are typically at 98% or above for synthesis-grade applications. Buyers sourcing for pharmaceutical or biotech use should confirm GMP-aligned documentation with their suppliers. Batch-level analytical data should be reviewed to ensure the material meets the necessary requirements. This ensures the solvent performs reliably in sensitive manufacturing and research environments. Contact us for supply of Tetrabutylurea Request Quote

Other Names (Synonyms)

1,1,3,3-Tetrabutylurea | UREA, TETRABUTYL- | Urea, 1,1,3,3-tetrabutyl- | Urea, N,N,N',N'-tetrabutyl- | 736CY99V47 | N,N,N′,N′-Tetrabutylurea | TBU

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-60 °C
Boiling Point173-174 °C @ Press: 4 Torr
Density0.8828 g/cm³
Flash Point93 °C
AppearanceLiquid. Insoluble in water. Combustible.
ColorColorless to Light yellow to Light orange
Formclear liquid
Water Solubility4.3mg/L at 20℃
Vapor Pressure0.019Pa at 20℃
Refractive Index1.4520-1.4560
Log P6.2 at 25℃

Safety & Handling

Warning
GHS09· Environment

Hazard Statements

H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary Statements

P273Avoid release to the environment.
P391Collect spillage.
P501Dispose of contents/container in accordance with local regulations.

Trade & Regulatory

HS Code2924.19.8000