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Disopyramide

CAS Number
3737-09-5
EC Number
223-110-2
Chemical Formula
C21H29N3O
Molecular Weight
339.5 g/mol

Description

Disopyramide (CAS 3737-09-5 ) is an active pharmaceutical ingredient used in the treatment of cardiac arrhythmias. It functions as a Class Ia antiarrhythmic agent, suppressing abnormal electrical activity in the heart muscle. This compound helps to restore and maintain normal sinus rhythm in patients. It is the primary API in finished oral dosage forms, including capsules and extended-release tablets, indicated for ventricular and supraventricular arrhythmias. Pharmaceutical manufacturers source this material as a key input for formulating branded and generic antiarrhythmic drug products. It is also used in hypertrophic obstructive cardiomyopathy management to reduce outflow tract obstruction. The clinical utility of this substance expands its relevance beyond standard arrhythmia indications. Research and reference standard laboratories procure small quantities for analytical method development and pharmacokinetic studies. The material is supplied as a white to off-white crystalline powder. It is available in pharmaceutical-grade specifications, including USP and BP / Ph.Eur. grades, to meet the quality requirements of regulated drug manufacturing. The phosphate salt form, Disopyramide Phosphate, is the more commonly used variant in finished dosage formulations. This salt is also available under corresponding pharmacopoeial standards such as EP for global distribution. Contact us for supply of Disopyramide Request Quote

Other Names (Synonyms)

gamma-diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide | alpha-[2-(diisopropylamino)ethyl]-alpha-phenyl-2-pyridineacetamide | Lispine | Isorythm | Rythmodan P | Ritmilen | Dl-disopyramide | 2-Pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point94.5-95 °C
Boiling Point475.43°C (rough estimate)
Density1.0779 (rough estimate)
AppearanceCrystalline Solid
ColorWhite
Formsolid
Water Solubility6.17mg/L(22.5 ºC)
Refractive Index1.6300 (estimate)

Safety & Handling

Warning
GHS07· IrritantGHS08· Health Hazard

Hazard Statements

H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P318IF exposed or concerned, get medical advice.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P317Get emergency medical help.

Trade & Regulatory

HS Code2933.39.4100
WGK (Germany)3