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Lamivudine

CAS Number
134678-17-4
EC Number
603-844-3
Chemical Formula
C8H11N3O3S
Molecular Weight
229.26 g/mol

Description

Lamivudine (CAS 134678-17-4 ), also known by the abbreviation 3TC and supplied under the trade name Heptovir, is a nucleoside reverse transcriptase inhibitor used as an active pharmaceutical ingredient. It is a core component in formulations targeting HIV and chronic hepatitis B, and is recognized globally as an essential API in both branded and generic pharmaceutical pipelines for global distribution. Lamivudine is primarily used in the manufacture of oral solid dosage forms, such as tablets and film-coated tablets, for HIV treatment regimens often combined with other antiretroviral APIs in products. Generic pharmaceutical manufacturers source it as a key API for hepatitis B antiviral therapies, where regulatory-grade purity is a critical procurement requirement for international safety standards. It is also used by formulators developing pediatric oral solutions, requiring specific solubility-compatible grades. Contract development and manufacturing organizations source it as a synthesis intermediate. Lamivudine is available as a white crystalline powder in pharmaceutical-grade specifications. Recognized grades include USP , BP , and Ph. Eur. , aligning with the requirements of regulated markets. These standards ensure compliance in North America, Europe, and beyond. Supply is typically offered in kilogram to metric-ton quantities, with documentation packages supporting GMP-compliant procurement. Contact us for supply of Lamivudine Request Quote

Other Names (Synonyms)

Lamivudin | Heptovir | GR-109714X | Epivir-Hbv | beta-L-3'-Thia-2',3'-dideoxycytidine | beta-L-2',3'-Dideoxy-3'-thiacytidine | 3TC | 3'-Thia-2',3'-dideoxycytidine

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point160-162 °C
Boiling Point475.4±55.0 °C(Predicted)
Density1.73±0.1 g/cm3(Predicted)
Flash Point9°C
AppearanceWhite Crystalline Powder
Colorwhite to beige
Formpowder
Water Solubility70g/L(temperature not stated)
Refractive Index-142 ° (C=1, MeOH)

Safety & Handling

Warning
GHS07· IrritantGHS08· Health Hazard

Hazard Statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29349900
UN Number1230
Packing GroupII
Storage Class11 - Combustible Solids
WGK (Germany)3