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Zidovudine

CAS Number
30516-87-1
EC Number
623-849-4
Chemical Formula
C10H13N5O4
Molecular Weight
267.24 g/mol

Description

Zidovudine (CAS 30516-87-1 ), also known as AZT and marketed under the brand name Retrovir®, is an antiretroviral nucleoside analogue used as an active pharmaceutical ingredient in HIV treatment formulations. It functions as a reverse transcriptase inhibitor, blocking viral replication at the enzymatic level and forming the basis of combination antiretroviral therapy regimens for patients worldwide. The primary application is as an API in oral solid and liquid dosage forms, including tablets, capsules, and syrups, manufactured for HIV/AIDS treatment protocols in the pharmaceutical industry. Zidovudine is also incorporated into fixed-dose combination products alongside other antiretrovirals, requiring precise blending and compatibility assessment during the formulation development process. Pharmaceutical manufacturers sourcing it as an intermediate use it in the synthesis of combination drug substances subject to stringent regulatory review and high quality control standards. Research institutions and generic drug developers procure it as a reference standard or starting material for bioequivalence and stability studies to ensure therapeutic efficacy and safety. Zidovudine is supplied as a white to off-white crystalline powder. It is available in USP , BP , and Ph. Eur. grades to meet the documentation requirements of regulated markets. Quantities range from research-scale to commercial bulk, with full batch documentation typically required by regulated-market buyers to ensure compliance with international manufacturing guidelines. Contact us for supply of Zidovudine Request Quote

Other Names (Synonyms)

Zidovudin | Retrovir® | AZT | 3'-azido-3'-deoxythymidine | ZDV | Thymidine, 3'-azido-3'-deoxy- | Compound S | BW A509U

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point106-112 °C
Boiling Point410.43°C (rough estimate)
Density1.3382 (rough estimate)
Flash Point9°C
AppearanceOff White Crystalline Powder
ColorWhite to Off-white
FormPowder
Water Solubility1-5 g/100 mL at 17 ºC
Refractive Index47 ° (C=1, H2O)

Safety & Handling

Danger
GHS08· Health Hazard

Hazard Statements

H341Suspected of causing genetic defects
H350May cause cancer
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy and while nursing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P316Get emergency medical help immediately.

Trade & Regulatory

HS Code29349900
UN Number1230
Packing GroupII
WGK (Germany)3