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Fmoc-L-tryptophan

CAS Number
35737-15-6
EC Number
252-706-5
Chemical Formula
C26H22N2O4
Molecular Weight
426.5 g/mol

Description

Fmoc-L-tryptophan (CAS 35737-15-6 ), commonly referenced as Fmoc-Trp-OH, is a protected amino acid building block used in solid-phase peptide synthesis (SPPS). The Fmoc protecting group allows sequential, controlled chain assembly under mild deprotection conditions, making this compound a standard reagent in peptide manufacturing workflows. In pharmaceutical peptide production, Fmoc-Trp-OH is incorporated into therapeutic peptide sequences where tryptophan residues are required for biological activity or structural integrity. Research and contract synthesis organizations use it to produce peptide APIs, peptide libraries, and reference standards at both discovery and scale. In biotechnology, it supports the synthesis of peptide-based probes, linkers, and conjugates used in diagnostic and analytical applications for various industries. Academic and industrial peptide chemists also rely on it for custom sequence development during early-stage drug candidate screening and development processes. Fmoc-Trp-OH is supplied as a white to off-white crystalline powder. It is available in research quantities through to multi-kilogram lots to support scale-up. Common grades include synthesis-grade for research use and higher-purity specifications aligned with requirements for commercial peptide manufacturing and production. Contact us for supply of Fmoc-L-tryptophan Request Quote

Other Names (Synonyms)

Nalpha-(9-Fluorenylmethoxycarbonyl)-L-tryptophan | Fmoc-Trp-OH | RefChem:599553 | Fmoc-L-Trp-OH | Nalpha-FMOC-L-Tryptophan | L-Tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- | (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)propanoic acid | N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tryptophan

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point86-90 °C
Boiling Point541.92°C (rough estimate)
Density1.2501 (rough estimate)
Appearancewhite to light yellow crystal powde
ColorWhite to Almost white
Formpowder to crystal
Refractive Index-28.5 ° (C=1, DMF)

Trade & Regulatory

HS Code29339900
Storage Class11 - Combustible Solids
WGK (Germany)3