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Dicyclohexylcarbodiimide

CAS Number
538-75-0
EC Number
208-704-1
Chemical Formula
C13H22N2
Molecular Weight
206.33 g/mol

Description

Dicyclohexylcarbodiimide (CAS 538-75-0 ), commonly known as DCC, is a coupling reagent used across pharmaceutical synthesis, peptide chemistry, and specialty chemical manufacturing. It activates carboxylic acids for condensation reactions, enabling the formation of amide, ester, and peptide bonds under mild conditions for various industrial applications. In pharmaceutical API synthesis, DCC drives amide bond formation in the production of active ingredients where selectivity and yield are critical procurement considerations. Peptide manufacturers rely on it as a standard coupling agent in both solution-phase and solid-phase peptide synthesis workflows for high-efficiency chemical production. In flavor and fragrance chemistry, DCC facilitates ester synthesis for aroma compound production where conventional acid-catalyzed routes are unsuitable for the final product. Cosmetic formulators use it in the synthesis of specialty esters and functional ingredients requiring controlled reaction conditions to ensure the stability of the formulation. DCC is supplied as a white to off-white crystalline solid. It is available in technical and high-purity reagent grades, with pharmaceutical-grade material meeting specifications. The material is suitable for GMP synthesis environments. Packaging ranges from laboratory-scale quantities to bulk supply for large-scale industrial synthesis operations. Contact us for supply of Dicyclohexylcarbodiimide Request Quote

Other Names (Synonyms)

N,N'-methanetetraylbiscyclohexaamine | N,N'-methanediylidenedicyclohexanamine | N,N'-dicyclohexylcarbodiimide | DCCD | bis(cyclohexyl)carbodiimide | DCCI | DCC | 1,3-dicyclohexylcarbodiimide

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point34.5 °C
Boiling Point112 °C @ Press: 3.5 Torr
Density1.247 g/mL at 25 °C
Flash Point190 °F
AppearanceN,N0 -Dicyclohexylcarbodiimide (DCC) is a white crystalline solid. Odor is sweet and heavy.
ColorWhite to pale yellow
FormWaxy Solid or Crystalline Mass
Water SolubilityReaction
Vapor Pressure1.044-1.15Pa at 20-25℃
Refractive Indexn 20/D 1.48
Log P5.567-6.83 at 25℃

Safety & Handling

Danger
GHS05· CorrosiveGHS06· ToxicGHS07· IrritantGHS09· EnvironmentGHS08· Health Hazard

Hazard Statements

H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H330Fatal if inhaled
H371May cause damage to organs
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
H413May cause long lasting harmful effects to aquatic life

Precautionary Statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284In case of inadequate ventilation wear respiratory protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P330Rinse mouth.
P391Collect spillage.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P317Get emergency medical help.
P364Take off immediately all contaminated clothing and wash it before reuse.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29251900
UN Number2922
ADR Class8
Packing GroupII
Storage Class6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects
WGK (Germany)3