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Ibuprofen

CAS Number
15687-27-1
EC Number
239-784-6
Chemical Formula
C13H18O2
Molecular Weight
206.28 g/mol

Description

Ibuprofen (CAS 15687-27-1 ) is a non-steroidal anti-inflammatory active pharmaceutical ingredient used across prescription and OTC drug manufacturing globally. Sourced in bulk API form, it functions as the primary analgesic agent. The largest commercial demand comes from OTC tablet and capsule production, where it is the active ingredient in pain relief and fever reduction products. Liquid suspension manufacturing represents a distinct high-volume segment. These pediatric formulations require specific particle size and solubility profiles to ensure efficacy. Topical pharmaceutical products, including gels and creams for localized pain, rely on defined concentrations for transdermal delivery. Contract manufacturers and generic drug producers also source this material as a starting material or intermediate. It is frequently used in the synthesis of ibuprofen lysinate and other specialized salt-form derivatives. The product is supplied as a white crystalline powder in bulk quantities, typically ranging from kilogram to multi-tonne lots. Standard grades include USP , BP , Ph.Eur. , and JP for global compliance. Grade selection is driven by the target market's regulatory requirements and specific formulation needs. Micronized grades are available for applications where enhanced dissolution rate or suspension uniformity is a priority. Contact us for supply of Ibuprofen Request Quote

Other Names (Synonyms)

α-(p-isobutylphenyl)propionic acid | α-(4-isobutylphenyl)propionic acid | U-18573 | p-isobutylhydratropic acid | p-isobutylhydratropate | p-isobutyl-2-phenylpropionic acid | p-isobutyl-2-phenylpropionate | alpha-p-isobutylphenylpropionic acid

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point75-77 °C
Boiling Point307.30 °C
Density0.453 g/cm³ (bulk)
Flash Point9°C
AppearanceColourless, Crystalline Solid
Colorwhite to off-white
FormCrystalline Powder
Water Solubilityinsoluble
Refractive Index1.5500 (estimate)
Log P3.970

Safety & Handling

Warning
GHS07· IrritantGHS08· Health HazardGHS09· Environment

Hazard Statements

H302Harmful if swallowed
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
H371May cause damage to organs
H373May causes damage to organs through prolonged or repeated exposure
H411Toxic to aquatic life with long lasting effects

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy and while nursing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P330Rinse mouth.
P391Collect spillage.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29163920
Storage Class11 - Combustible Solids
WGK (Germany)3