HomeProducts
Amines REACH

Synephrine

CAS Number
94-07-5
EC Number
202-300-9
Chemical Formula
C9H13NO2
Molecular Weight
167.20 g/mol

Description

Synephrine (CAS 94-07-5 ), also known as p-synephrine, is a naturally occurring alkaloid extracted primarily from bitter orange. It functions as an adrenergic agonist active ingredient in pharmaceutical formulations. The compound is used across nutraceutical and cosmetic applications as a bioactive compound. In pharmaceutical manufacturing, it serves as an active ingredient in preparations targeting nasal congestion and circulatory support. Its adrenergic activity drives formulation decisions for various medical applications. Nutraceutical producers incorporate it into weight management and sports nutrition products as a stimulant-adjacent botanical extract. This application is particularly common following restrictions on ephedrine-based ingredients. In topical cosmetic formulations, it is used for its skin-firming and anti-cellulite positioning in slimming creams. Contract manufacturers also source it as a pharmaceutical intermediate for synthesizing structurally related adrenergic compounds. Synephrine is supplied as a white to off-white crystalline powder. Standard commercial grades include pharmaceutical-grade material meeting USP or BP specifications. Technical-grade material is also available for industrial synthesis and chemical processing. High-purity extracts standardized from Citrus aurantium are available for nutraceutical and dietary supplement applications. These extracts ensure consistent potency and quality for global manufacturing standards. Contact us for supply of Synephrine Request Quote

Other Names (Synonyms)

p-synephrine | p-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol | beta-methylamino-alpha-(4-hydroxyphenyl)ethyl alcohol | 4-hydroxy-alpha-[(methylamino)methyl]benzenemethanol | 4-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol | 1-(4-hydroxyphenyl)-2-methylaminoethanol | Sympatol | Oxedrine

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point184.5 °C
Boiling Point341.1 °C @ Press: 760 Torr
Density1.1222 (rough estimate)
AppearanceOff-White to Beige Powder
ColorWhite to Off-White
Formneat
Refractive Index1.4680 (estimate)
Log P-0.450

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29225000
WGK (Germany)3