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Amines REACH

Cyclopropylamine

CAS Number
765-30-0
EC Number
212-142-2
Chemical Formula
C3H7N
Molecular Weight
57.09 g/mol

Description

Cyclopropylamine (CAS 765-30-0 ) is a strained-ring primary amine used as a reactive building block in pharmaceutical synthesis and specialty polymer chemistry. The abbreviation CPA appears in procurement and research contexts as a recognized shorthand. Its combination of amine reactivity and ring strain makes it a valued intermediate for constructing complex molecular architectures at scale. In pharmaceutical manufacturing, it is incorporated into active pharmaceutical ingredient synthesis. This chemical is particularly useful in the preparation of kinase inhibitors, antidepressants, and other small-molecule drug candidates where the cyclopropyl motif improves metabolic stability. Polymer chemists use it as a curing agent. It acts as a cross-linker in epoxy and specialty resin systems, where controlled amine reactivity influences final network density and mechanical performance. In agrochemical development, it serves as a key intermediate for herbicide synthesis. Biotech research applications include its use as a building block for probe compounds and enzyme inhibitors in target-based drug discovery programs. It is supplied as a colorless to pale yellow liquid in various packaging. Options range from small research quantities to bulk drums and IBC containers. Technical and high-purity grades are available, with purity specifications typically from 98% up to 99%+ for pharmaceutical intermediate use. Certificate of Analysis documentation aligned with GMP procurement requirements is standard for pharma-grade supply. This ensures the material meets the rigorous demands of modern chemical manufacturing and laboratory research. Contact us for supply of Cyclopropylamine Request Quote

Other Names (Synonyms)

8PR8XTH1X1 | RefChem:581232 | CPA

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-35.4 °C
Boiling Point49-50 °C
Density0.824 g/mL at 25 °C(lit.)
Flash Point−14 °F
Appearanceclear colorless to very slightly yellow liquid
ColorClear colorless
FormVolatile Liquid
Water SolubilityMiscible with water, ethanol,ether and chloroform.
Vapor Pressure4.67 psi ( 20 °C)
Refractive Indexn 20/D 1.420(lit.)
Log P0.070

Safety & Handling

Danger
GHS02· FlammableGHS05· CorrosiveGHS07· Irritant

Hazard Statements

H225Highly Flammable liquid and vapor
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H318Causes serious eye damage
H332Harmful if inhaled
H412Harmful to aquatic life with long lasting effects H302+
H332Harmful if swallowed or if inhaled

Precautionary Statements

P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P235Store in a well-ventilated place. Keep cool.
P331Rinse mouth. Do NOT induce vomiting.
P354IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29213099
UN Number2733
ADR Class3
Packing GroupII
WGK (Germany)2