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Trichloroacetic acid

CAS Number
76-03-9
EC Number
200-927-2
Chemical Formula
C2HCl3O2
Molecular Weight
163.38 g/mol

Description

Trichloroacetic acid ( CAS 76-03-9 ), commonly abbreviated as TCA, is a strong chlorinated organic acid used across pharmaceutical, cosmetic, and industrial processing applications. It functions primarily as a protein precipitant and chemical denaturant. This chemical enables controlled tissue destruction, protein removal, and surface treatment in manufacturing workflows. In pharmaceutical and laboratory settings, TCA is used to precipitate proteins from biological samples for analysis. It serves as a standard reagent in analytical and quality control procedures. The cosmetic industry applies it in controlled chemical peel formulations, where it removes damaged or keratinized skin layers at defined concentrations. Textile and leather processors use TCA as a chemical treatment agent to modify fiber surfaces and support dyeing or finishing operations. It also functions as a biocide and preservation agent in industrial formulations. This versatile acid is essential where microbial control is required. Trichloroacetic acid is supplied as a crystalline solid or in aqueous solution at various concentrations, with high-concentration solutions common for industrial use. Established grades include pharmaceutical-grade and reagent-grade material meeting USP and BP specifications. Technical-grade material is available for industrial processing applications where pharmacopeial compliance is not required. Contact us for supply of Trichloroacetic acid Request Quote

Other Names (Synonyms)

trichloroethanoic acid | trichloracetic acid | TCA | Aceto-caustin | Acetic acid, trichloro- | Konesta | 2,2,2-trichloroacetic acid | Acetic acid, 2,2,2-trichloro-

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point57.5 °C
Boiling Point195.5 °C
Density1.6126 g/cm³ @ Temp: 64 °C
Flash Point196°C
AppearanceTrichloroacetic acid is a colorless crystalline solid which is used in liquid solutions.
ColorWhite
Odorsharp, pungent odor
FormSolid
Water Solubility120 g/100 mL (20 ºC)
Vapor Pressure1 mm Hg ( 51 °C)
Refractive Indexn 20/D 1.62(lit.)
pH<1.0 (25℃, 0.5M in H2O)
Log P1.330

Safety & Handling

Danger
GHS05· CorrosiveGHS09· EnvironmentGHS08· Health HazardGHS07· Irritant

Hazard Statements

H303May be harmful if swallowed
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H336May cause drowsiness or dizziness
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
H371May cause damage to organs
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P391Collect spillage.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P233Store in a well-ventilated place. Keep container tightly closed.
P331Rinse mouth. Do NOT induce vomiting.
P354IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29154000
UN Number1839
ADR Class8
Packing GroupII
Storage Class8B - Non-combustible corrosive hazardous materials
WGK (Germany)2