HomeProducts
Solvents REACH

Diethyl sulfate

CAS Number
64-67-5
EC Number
200-589-6
Chemical Formula
C4H10O4S
Molecular Weight
154.19 g/mol

Description

Diethyl sulfate ( CAS 64-67-5 ), also known as DES, is a reactive diethyl ester of sulfuric acid used industrially as an ethylating agent. It transfers ethyl groups to amines, alcohols, and other nucleophiles. This functionality enables the synthesis of ethylated intermediates across pharmaceutical, agrochemical, and specialty chemical manufacturing. In pharmaceutical synthesis, DES alkylates active pharmaceutical ingredients and intermediates. It is particularly useful where controlled ethylation is required at scale. Agrochemical producers use it to manufacture ethylated herbicide and pesticide intermediates, especially where other agents present disadvantages. In personal care chemistry, DES supports the production of ethylated surfactants and conditioning agents used in finished formulations. It also functions as a solvent and carrier in select chemical processes. The reactivity profile of this compound must be compatible with the target substrate for optimal results. Diethyl sulfate is supplied as a liquid, typically in drum and IBC quantities suited to industrial consumption. Technical grade is the standard commercial offering, with purity specifications commonly at 99% minimum. Buyers sourcing for pharmaceutical intermediate production should confirm supplier documentation carefully. Ensure all materials meet applicable regulatory requirements for your specific jurisdiction. This product is a critical component for high-volume chemical synthesis and industrial manufacturing applications worldwide. Contact us for supply of Diethyl sulfate Request Quote

Other Names (Synonyms)

Diethyl sulphate | Sulfuric acid, diethyl ester | Diethyl tetraoxosulfate | Diethylester kyseliny sirove | K0FO4VFA7I | Ethyl sulfate (Et2SO4) | Ethyl sulfate | DES

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-25 °C
Boiling Point90-91 °C @ Press: 12 Torr
Density1.172 g/cm³ @ Temp: 25 °C
Flash Point173 °F
Appearancecolourless oily liquid
ColorClear
Odorchar. faint ether odor, irritating after-effect
FormLiquid
Water Solubility5 g/L (20 ºC)
Vapor Pressure<0.01 mm Hg ( 20 °C)
Refractive Indexn 20/D 1.399(lit.)

Safety & Handling

Danger
GHS05· CorrosiveGHS07· IrritantGHS08· Health HazardGHS06· Toxic

Hazard Statements

H302Harmful if swallowed
H311Toxic in contact with skin
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H331Toxic if inhaled
H332Harmful if inhaled
H340May cause genetic defects
H350May cause cancer
H371May cause damage to organs
H412Harmful to aquatic life with long lasting effects

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P364Take off immediately all contaminated clothing and wash it before reuse.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P331Rinse mouth. Do NOT induce vomiting.
P354IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29209090
UN Number1594
ADR Class6.1
Packing GroupII
Storage Class6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
WGK (Germany)3