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Ethyl 2-aminothiazole-4-carboxylate

CAS Number
5398-36-7
EC Number
611-074-4
Chemical Formula
C6H8N2O2S
Molecular Weight
172.21 g/mol

Description

Ethyl 2-aminothiazole-4-carboxylate (CAS 5398-36-7 ) is a thiazole-based building block used primarily as a pharmaceutical intermediate in the synthesis of active pharmaceutical ingredients. The compound's aminothiazole scaffold makes it a recognized starting material or coupling partner in multi-step synthetic routes targeting antibiotics, antivirals, and other therapeutic compounds. In pharmaceutical manufacturing, it serves as a key intermediate in the synthesis of cephalosporin antibiotics and related beta-lactam compounds, where the aminothiazole moiety is a structurally critical fragment. Medicinal chemistry programs use it in the construction of heterocyclic libraries for drug discovery, particularly in campaigns targeting antimicrobial and antifungal candidates. Contract manufacturers and API producers source it as a building block for regulated synthesis workflows requiring documented purity and traceability for high-quality chemical production. Specialty chemical formulators also evaluate it within heterocyclic compound programs for fine chemical and agrochemical research applications across various industrial sectors. Ethyl 2-aminothiazole-4-carboxylate is supplied as a solid powder, typically off-white to pale yellow in appearance. It is available in research quantities through to multi-kilogram commercial lots. Purity specifications commonly offered include 97–99%+ grades suited to pharmaceutical intermediate and synthesis applications, ensuring reliability in complex chemical manufacturing processes. Contact us for supply of Ethyl 2-aminothiazole-4-carboxylate Request Quote

Other Names (Synonyms)

Ethyl 2-amino-1,3-thiazole-4-carboxylate | RefChem:594217 | Ethyl 2amino4thiazolecarboxylate | 4Thiazolecarboxylic acid, 2amino, ethyl ester | 2-Amino-4-(ethoxycarbonyl)-1,3-thiazole | 2-Amino-4-thiazolecarboxylic acid ethyl ester | 2-Amino-4-ethoxycarbonylthiazole

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point142.5-144.2 °C
Boiling Point308.0±15.0 °C(Predicted)
Density1.336±0.06 g/cm3(Predicted)
Appearancewhite crystal powde
ColorPale Beige
FormSolid

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P317Get emergency medical help.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29341000
Storage Class11 - Combustible Solids
WGK (Germany)nwg