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Sodium beta-naphthoquinone-4-sulfonate

CAS Number
521-24-4
EC Number
208-308-9
Chemical Formula
C10H6O5S.Na
Molecular Weight
260.20 g/mol

Description

Sodium beta-naphthoquinone-4-sulfonate (CAS 521-24-4 ), commonly abbreviated as NQS, is a water-soluble quinone reagent used in analytical and pharmaceutical chemistry. It functions as a chromogenic derivatizing agent, reacting with primary and secondary amines to produce colored complexes measurable by spectrophotometry for various applications. NQS is used in pharmaceutical quality control for the colorimetric determination of amino-containing active pharmaceutical ingredients, including sulfonamides and aminoglycosides. This enables quantitative assay development without chromatographic separation. In clinical and biochemical analysis, it supports the detection and quantification of amino acids. Biotechnology workflows use NQS as a labeling reagent for amine-functionalized compounds, supporting assay development and compound characterization at research and pilot scale. It also appears in the development of stability-indicating methods, where its selective reactivity with amine groups helps identify degradation products in drug formulations. Sodium beta-naphthoquinone-4-sulfonate is supplied as a solid powder, typically in high-purity grades suited for analytical and pharmaceutical research applications. Material is generally available at reagent or research grade, with purity specifications commonly at 97% or higher. Packaging ranges from small laboratory quantities to bulk orders. Contact us for supply of Sodium beta-naphthoquinone-4-sulfonate Request Quote

Other Names (Synonyms)

1,2-Naphthoquinone-4-sulfonic acid sodium salt | beta-Naphthoquinone-4-sulfonate sodium salt | T7185HP5SH | AI3-50008 | Sodium 3,4-dihydro-3,4-dioxo-1-naphthalenesulfonate | 1-Naphthalenesulfonic acid, 3,4-dihydro-3,4-dioxo-, sodium salt (1:1) | 1-Naphthalenesulfonic acid, 3,4-dihydro-3,4-dioxo-, sodium salt | β-Naphthoquinone-4-sulfonate sodium salt | NQS

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
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Physical Properties

Melting Point287 °C (decomp)
Appearancepowder
Colordark orange
OdorOdorless
Formsolid
Water SolubilitySoluble in water and acetone. Slightly soluble in alcohol and ethanol. Insoluble in chloroform.

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29147000
WGK (Germany)3