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Metronidazole

CAS Number
443-48-1
EC Number
207-136-1
Chemical Formula
C6H9N3O3
Molecular Weight
171.15 g/mol

Description

Metronidazole (CAS 443-48-1 ) is an antiprotozoal and antibacterial active pharmaceutical ingredient used across human and veterinary medicine. It targets anaerobic bacteria and protozoa, making it a core API in prescription drug manufacturing globally. In pharmaceutical manufacturing, this active is formulated into oral tablets, suspensions, and intravenous solutions for treating infections caused by anaerobic organisms. These include bacterial vaginosis, trichomoniasis, and Clostridioides difficile. Topical formulations such as gels and creams are produced for dermatological indications, including rosacea management. Here, the active is incorporated at defined concentrations into semi-solid bases for targeted delivery. Veterinary drug manufacturers use the compound in oral and injectable preparations targeting gastrointestinal anaerobic infections. These applications are common in both companion animals and livestock health management. In cosmetic and personal care formulations, it appears in select anti-redness and skin-calming products. This occurs where regulatory frameworks permit its use as an active ingredient for specific skin conditions. The material is supplied as a white to off-white crystalline powder. It is available in USP , BP , and Ph. Eur. pharmacopoeial grades to meet the documentation requirements of regulated pharmaceutical markets. API-grade material is the standard commercial form for industrial use. Micronized particle size variants are also available to support specific formulation requirements and ensure optimal bioavailability in finished products. Contact us for supply of Metronidazole Request Quote

Other Names (Synonyms)

2-methyl-5-nitroimidazole-1-ethanol | 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole | 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole | 1-(β-oxyethyl)-2-methyl-5-nitroimidazole | 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole | 1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole | 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole | 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point158-160 °C
Boiling Point301.12°C (rough estimate)
Density1.45 g/cm³
Flash Point9°C
AppearanceMetronidazole is an odorless, white, yellow, or cream-colored crystalline solid. Darkens on exposure to light. Bitter, salty taste (do not test).
Colorwhite to light yellow
Formcrystalline
Water Solubility<0.1 g/100 mL at 20 ºC
Refractive Index1.5800 (estimate)
Log P-0.02

Safety & Handling

Danger
GHS07· IrritantGHS08· Health Hazard

Hazard Statements

H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
H341Suspected of causing genetic defects
H350May cause cancer
H351Suspected of causing cancer
H373May causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P364Take off contaminated clothing and wash it before reuse.

Trade & Regulatory

HS Code29332990
Storage Class6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany)3