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4-bromophenyl isocyanate

CAS Number
2493-02-9
EC Number
219-662-9
Chemical Formula
C7H4BrNO
Molecular Weight
198.02 g/mol

Description

4-Bromophenyl isocyanate (CAS 2493-02-9 ), also known as p-bromophenyl isocyanate, is a reactive aryl isocyanate used as a building block in organic synthesis and polymer chemistry. The bromine substituent provides a handle for further functionalization, making it a practical intermediate for constructing complex molecular architectures in pharmaceutical and specialty chemical workflows. In pharmaceutical synthesis, it serves as a key intermediate for preparing urea-containing drug candidates and bioactive compounds where the bromine atom enables downstream cross-coupling reactions. Agrochemical and fine chemical manufacturers use it to introduce the bromophenyl-urea motif into active ingredient scaffolds. In polymer research, it functions as a monomer for producing specialty polyureas. Biotechnology researchers also employ it in the preparation of labeled probes and derivatization reagents for analytical applications. It is supplied as a liquid or low-melting solid in high-purity grades. Standard offerings include reagent-grade and synthesis-grade material, with purity specifications commonly at 97% or higher by GC. Packaging ranges from small quantities to bulk quantities for industrial use. Contact us for supply of 4-bromophenyl isocyanate Request Quote

Other Names (Synonyms)

p-Bromophenyl isocyanate | 4-bromophenylcarbimide | Isocyanic acid, p-bromophenyl ester | MGR77M31ZW | P-BROMOPHENYLCARBONIMIDE | Benzene, 1-bromo-4-isocyanato- | 1-Bromo-4-isocyanatobenzene

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point134 °C
Boiling Point78-80 °C @ Press: 5 Torr
Density1.6077 (rough estimate)
Flash Point229 °F
AppearanceWHITE TO LIGHT BEIGE CRYSTALLINE SOLID
ColorWhite to light beige
FormCrystalline Solid
Water SolubilitySparingly soluble in water (0.40 g/L at 25°C).
Refractive Index1.5500 (estimate)

Safety & Handling

Danger
GHS07· IrritantGHS08· Health Hazard

Hazard Statements

H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation

Precautionary Statements

P233Keep container tightly closed.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284In case of inadequate ventilation wear respiratory protection.
P317Get emergency medical help.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P403Store in a well-ventilated place.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P316Get emergency medical help immediately.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29291090
WGK (Germany)3