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Esomeprazole sodium

CAS Number
161796-78-7
EC Number
620-470-6
Chemical Formula
C17H19N3O3S.Na
Molecular Weight
367.4 g/mol

Description

Esomeprazole sodium (CAS 161796-78-7 ), also referenced in clinical and procurement contexts as Nexium IV, is the sodium salt form of the S-enantiomer of omeprazole. It was developed for intravenous pharmaceutical applications. It functions as a proton pump inhibitor (PPI) active pharmaceutical ingredient (API), suppressing gastric acid secretion for therapeutic formulation use. The primary application is in the manufacture of injectable formulations. These formulations are used for hospital and clinical settings where rapid acid suppression is required when oral administration is not feasible. It is used by pharmaceutical manufacturers producing IV solutions for various conditions. Common uses include gastroesophageal reflux disease and stress ulcer prophylaxis in critical care patients. Formulators also source it as the API for lyophilized powder-for-injection presentations for aqueous parenteral systems. The sodium salt form supports specific solubility requirements in these systems. Generic drug manufacturers targeting regulated markets rely on it as the reference-aligned active for biosimilar and generic IV PPI product development. Esomeprazole sodium is supplied as a white to off-white lyophilized powder or crystalline solid. It is available in pharmaceutical-grade specifications aligned with USP and Ph. Eur. monograph requirements. Sourcing is typically in small-to-medium quantities suited to API procurement workflows. Documentation packages are provided to support regulatory submissions and ensure compliance with international pharmaceutical standards. Contact us for supply of Esomeprazole sodium Request Quote

Other Names (Synonyms)

Nexium IV | H199/18 sodium | Esomeprazole (as sodium) | L2C9GWQ43H | RefChem:55133

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point~156 °C (approx)
ColorPale Beige to Brown
FormSolid

Safety & Handling

Warning
GHS07· IrritantGHS09· Environment

Hazard Statements

H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H411Toxic to aquatic life with long lasting effects
H412Harmful to aquatic life with long lasting effects

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P391Collect spillage.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

Storage Class11 - Combustible Solids
WGK (Germany)3