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Rabeprazole

CAS Number
117976-89-3
EC Number
601-501-2
Chemical Formula
C18H21N3O3S
Molecular Weight
359.4 g/mol

Description

Rabeprazole (CAS 117976-89-3 ), also referenced in development literature as E-3810 and LY307640, is a proton pump inhibitor (PPI) active pharmaceutical ingredient used in the treatment of acid-related gastrointestinal disorders. It functions by irreversibly suppressing gastric acid secretion, making it a target API for finished dosage form manufacturers and generic drug developers worldwide. Rabeprazole is the active ingredient in delayed-release oral solid dosage forms. These are primarily enteric-coated tablets and capsules formulated to treat conditions such as gastroesophageal reflux disease, peptic ulcers, and Zollinger-Ellison syndrome. Generic pharmaceutical manufacturers source the API to produce bioequivalent formulations. These formulations are intended for regulated markets in the US, EU, and Asia-Pacific. Contract development and manufacturing organizations (CDMOs) also procure it for combination therapies, including H. pylori eradication regimens paired with antibiotics. Formulators working on pediatric or modified-release formats may source it as an intermediate for specialized dosage development. Rabeprazole is supplied as a white to off-white crystalline powder. The sodium salt form (Rabeprazole Sodium) is the predominant commercial grade. Material is available to USP , BP , and Ph. Eur. pharmacopoeial standards, supporting regulatory submissions across major markets. Packaging is typically offered under inert atmosphere or moisture-controlled conditions to maintain API integrity during storage and transit. This ensures the chemical stability required for long-term pharmaceutical manufacturing. Contact us for supply of Rabeprazole Request Quote

Other Names (Synonyms)

E-3810 | Eraloc | 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1H-benzimidazole | E-3810 (PPI) | 2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole | 2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methyl]sulfinyl]benzimidazole | Rabeprazole Sodium

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point99-100 °C (decomp)
Boiling Point603.9±65.0 °C(Predicted)
Density1.33±0.1 g/cm3(Predicted)
ColorLight Brown to Very Dark Brown
FormSolid

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.