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Fexofenadine hydrochloride

CAS Number
153439-40-8
EC Number
604-906-2
Chemical Formula
C32H39NO4.ClH
Molecular Weight
538.1 g/mol

Description

Fexofenadine hydrochloride (CAS 153439-40-8 ), marketed under the brand name Allegra, is a second-generation antihistamine active pharmaceutical ingredient used in the manufacture of prescription and OTC allergy relief products. It targets peripheral H1 receptors without significant CNS penetration, making it a preferred API for non-sedating antihistamine formulations. The primary use is in finished oral dosage forms such as tablets and capsules. These products are indicated for seasonal allergic rhinitis and chronic idiopathic urticaria. Contract manufacturers and generic drug producers source it as the active ingredient in branded and private-label antihistamine products. In personal care, it is evaluated for inclusion in topical formulations targeting skin hypersensitivity and allergic dermatitis responses. Pharmaceutical formulators also utilize it in pediatric oral suspension development. Precise particle size and solubility profiles influence grade selection for these liquid applications. Fexofenadine hydrochloride is supplied as a white to off-white crystalline powder for industrial use. It is available in USP , BP , and Ph. Eur. compendial grades to meet regulatory requirements across major markets. Bulk quantities are typically offered for large scale pharmaceutical manufacturing. Micronized grades are available to support specific dissolution and bioavailability targets. This ensures the API meets the rigorous standards required for modern drug delivery systems and patient safety protocols. Contact us for supply of Fexofenadine hydrochloride Request Quote

Other Names (Synonyms)

Allegra | FEXOFENADINE HCL | Allegra Allergy | Allegra Hives | MDL 16,455A | Children's Allegra Hives | Children's Allegra Allergy

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point168.9 °C
AppearanceOff-White Crystalline Solid
Colorwhite to beige
Formpowder

Safety & Handling

Danger
GHS07· IrritantGHS08· Health Hazard

Hazard Statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code2933399090
WGK (Germany)3