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1,4-dioxane

CAS Number
123-91-1
EC Number
204-661-8
Chemical Formula
C4H8O2
Molecular Weight
88.11 g/mol

Description

1,4-Dioxane (CAS 123-91-1 ) is a cyclic ether solvent used across chemical manufacturing, laboratory research, and industrial processing. It functions as a high-solvency carrier for resins and cellulose derivatives. This versatile compound is effective for a broad range of organic compounds where other solvents underperform. In pharmaceutical and chemical synthesis, it serves as a reaction solvent and extraction medium. It is particularly useful in processes requiring miscibility with both water and organic phases. Personal care manufacturers monitor it as a trace contaminant in ethoxylated ingredients for safety. The chemical acts as a reference standard for quality control and regulatory compliance testing. In laboratory settings, it is used as a scintillation solvent and as a stabilizer carrier. It is also utilized in analytical-grade preparations for various research applications. Food and fragrance applications involve its use as a trace flavoring reference compound for testing. Despite these niche uses, its primary commercial demand remains in industrial solvent and synthesis roles. The product is supplied as a colorless liquid in drums and bulk containers. Standard grades include technical, reagent, and HPLC-grade, with anhydrous specifications available. These are ideal for moisture-sensitive synthesis applications in controlled environments. Stabilized and unstabilized variants are both commercially available for purchase. Grade selection is typically driven by specific end-use process requirements and stability needs. Contact us for supply of 1,4-dioxane Request Quote

Other Names (Synonyms)

tetrahydro-para-dioxin | tetrahydro-p-dioxin | tetrahydro-1,4-dioxin | p-Dioxane | glycol ethylene ether | dioxane-1,4 | Dioxan | Diethylene ether

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point11.80 °C
Boiling Point101.1 °C @ Press: 760 Torr
Density1.0337 g/cm³ @ Temp: 20 °C
Flash Point54 °F
Appearancecolourless liquid
ColorAPHA: ≤20
OdorMild ether-like odor detectable at 0.8 to 172 ppm (mean = 12 ppm)
FormSolution
Water SolubilitySOLUBLE
Vapor Pressure27 mm Hg ( 20 °C)
Refractive Indexn 20/D 1.422(lit.)
pH6-8 (500g/l, H2O, 20℃)
Log P-0.42 at 20℃

Safety & Handling

Danger
GHS02· FlammableGHS07· IrritantGHS08· Health HazardGHS06· Toxic

Hazard Statements

H225Highly Flammable liquid and vapor
H313May be harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H332Harmful if inhaled
H335May cause respiratory irritation
H336May cause drowsiness or dizziness
H350May cause cancer
H351Suspected of causing cancer
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
H373May causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P233Store in a well-ventilated place. Keep container tightly closed.
P235Store in a well-ventilated place. Keep cool.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29329900
UN Number1993
ADR Class3
Packing GroupII
Storage Class3 - Flammable liquids
WGK (Germany)3