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Amines REACH

Tetramethylhexamethylenediamine

CAS Number
111-18-2
EC Number
203-842-9
Chemical Formula
C10H24N2
Molecular Weight
172.31 g/mol

Description

Tetramethylhexamethylenediamine ( CAS 111-18-2 ), commonly abbreviated as TMHDA, is a tertiary diamine used across polymer chemistry, catalysis, and specialty chemical synthesis. Known also as 1,6-Bis(dimethylamino)hexane, it functions primarily as a catalyst, curing agent, and pH modifier in industrial formulations. In polyurethane and epoxy systems, it acts as a curing and crosslinking agent. It influences gel time and final network density, which are parameters critical to formulators specifying mechanical performance. It serves as a catalyst precursor in organometallic and coordination chemistry. Its bifunctional amine structure supports ligand design for pharmaceutical and fine chemical synthesis. In personal care formulations, it contributes to pH regulation in systems requiring controlled alkalinity. This is achieved without introducing ionic burden. Polymer producers also use it as a chain extender or modifier in specialty nylon and polyamide development for various industrial applications. TMHDA is supplied as a liquid at standard commercial purity levels, typically 98% or higher. Technical grade is the most common specification for industrial polymer and catalyst applications. Pharmaceutical-grade supply is available from select manufacturers where synthesis intermediates require tighter impurity profiles. Buyers should confirm specification documentation on a supplier-by-supplier basis. Contact us for supply of Tetramethylhexamethylenediamine Request Quote

Other Names (Synonyms)

1,6-Bis(dimethylamino)hexane | Hexamethylenebis(dimethylamine) | 1,6-HEXANEDIAMINE, N,N,N',N'-TETRAMETHYL- | Toyocat MR | Koolizer 1 | Minico TMHD | NIAX catalyst C-210 | U 1000 (amine) | TMHDA

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-46 °C
Boiling Point104 °C @ Press: 16 Torr
Density0.7981 g/cm³ @ Temp: 20 °C
Flash Point165 °F
Appearanceclear colorless to yellow liquid
ColorClear colorless to yellow
FormLiquid
Water Solubilitymiscible
Vapor Pressure12.4Pa at 20℃
Refractive Indexn 20/D 1.4359(lit.)
Log P1.99 at 23℃

Safety & Handling

Danger
GHS05· CorrosiveGHS06· ToxicGHS07· IrritantGHS08· Health HazardGHS09· Environment

Hazard Statements

H227Combustible liquid
H301Toxic if swallowed
H302Harmful if swallowed
H311Toxic in contact with skin
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H330Fatal if inhaled
H331Toxic if inhaled
H373May causes damage to organs through prolonged or repeated exposure
H402Harmful to aquatic life
H411Toxic to aquatic life with long lasting effects
H412Harmful to aquatic life with long lasting effects H301+
H311Toxic if swallowed or in contact with skin H301+H311+
H331Toxic if swallowed, in contact with skin or if inhaled

Precautionary Statements

P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284In case of inadequate ventilation wear respiratory protection.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P319Get medical advice/attention if you feel unwell.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P391Collect spillage.
P403Store in a well-ventilated place.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P364Take off immediately all contaminated clothing and wash it before reuse.
P378Use … for extinction.
P233Store in a well-ventilated place. Keep container tightly closed.
P331Rinse mouth. Do NOT induce vomiting.
P354IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29212900
UN Number3390
ADR Class6.1
Packing GroupI
WGK (Germany)1