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Hexamidine diisethionate

CAS Number
659-40-5
EC Number
211-533-5
Chemical Formula
C20H26N4O2.2C2H6O4S
Molecular Weight
606.7 g/mol

Description

Hexamidine diisethionate (CAS 659-40-5 ), also sold as hexamidine isethionate, is a broad-spectrum antimicrobial active used in pharmaceutical and cosmetic formulations. It targets bacteria, fungi, and protozoa, making it a reliable preservative and biocide. In topical products where microbial control is a formulation requirement, this compound provides consistent efficacy. In cosmetics, it functions as a preservative in rinse-off and leave-on products including shampoos and facial cleansers. It is frequently utilized as a paraben-free alternative in moisturizers and other personal care items. Topical pharmaceutical preparations, such as antiseptic creams and eye drops, use it as the primary antimicrobial active at low effective concentrations. The material also appears in contact lens care solutions, where its activity against Acanthamoeba addresses a specific microbial risk. This risk is often not covered by many standard preservatives used in ophthalmic applications. Wound care and skin antiseptic formulations incorporate it where a water-soluble, low-irritation biocide is preferred. The chemical is supplied as a white to off-white powder suitable for various industrial and medical manufacturing processes. It is available in cosmetic-grade and pharmaceutical-grade specifications, with the latter subject to purity requirements aligned with pharmacopoeial standards such as Ph.Eur. , BP , and EP . Packaging is typically offered in kilogram quantities for development-scale procurement and larger bulk formats for commercial production. Our supply chain ensures consistent quality and documentation for all industrial chemical requirements. Contact us for supply of Hexamidine diisethionate Request Quote

Other Names (Synonyms)

Hexamidine isethionate | hexomedin | hexamidine isetionate | 023XA5Z50L | Laryngomedin N | Benzamidine, 4,4′-(hexamethylenedioxy)di-, diisethionate

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point246-247° (dec)
Density671[at 20℃]
AppearanceWhite or slightly yellow powder, hygroscopic
Formneat
Water Solubility48.2g/L at 20℃
Vapor Pressure0Pa at 20℃
Log P4.47 at 25℃

Safety & Handling

Warning
GHS07· IrritantGHS09· Environment

Hazard Statements

H302Harmful if swallowed
H319Causes serious eye irritation
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
H411Toxic to aquatic life with long lasting effects

Precautionary Statements

P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P330Rinse mouth.
P391Collect spillage.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

Storage Class11 - Combustible Solids
WGK (Germany)3