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Terephthalaldehyde

CAS Number
623-27-8
EC Number
210-784-8
Chemical Formula
C8H6O2
Molecular Weight
134.13 g/mol

Description

Terephthalaldehyde (CAS 623-27-8 ), also known as 1,4-Benzenedicarboxaldehyde, is a bifunctional aromatic dialdehyde used as a reactive building block and crosslinking agent across polymer chemistry and pharmaceutical synthesis. Its two aldehyde groups enable controlled condensation and crosslinking reactions that underpin a range of advanced material and formulation processes. In polymer and materials science, it functions as a monomer for synthesizing polyimines. It is also utilized for covalent organic frameworks and high-performance resins where precise crosslink density is required. Pharmaceutical and biotech manufacturers use it as an intermediate in active ingredient synthesis. The compound serves as a protein crosslinker for diagnostic reagents and bioconjugation workflows. In personal care, it contributes to fragrance formulations where its aromatic aldehyde character supports specific scent profiles. Antimicrobial and preservation applications also draw on its biocidal activity, particularly in industrial disinfection and surface treatment formulations. This versatility makes it a staple in specialty chemical manufacturing. Terephthalaldehyde is supplied as an off-white to pale yellow crystalline solid. It is available in technical and high-purity grades, with reagent- and synthesis-grade specifications commonly offered for procurement. Packaging ranges from kilogram quantities for laboratory and development use to bulk quantities for industrial-scale production. This ensures consistent supply for both research and large-scale manufacturing needs. Contact us for supply of Terephthalaldehyde Request Quote

Other Names (Synonyms)

1,4-Benzenedicarboxaldehyde | 1,4-Phthalaldehyde | M2Y6E4N2TS | P-DIFORMYLBENZENE | Terephthalic aldehyde | 1,4-Diformylbenzene | p-Benzenedicarboxaldehyde | TPA

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point117 °C
Boiling Point290 °C
Density1.519 g/cm³
Flash Point76 °C
AppearanceWHITE TO LIGHT YELLOW CRYSTALLINE POWDER
ColorWhite to light yellow
FormCrystalline Powder
Water Solubility3 g/L (50 ºC)
Vapor Pressure0.25-0.46Pa at 20-25℃
Refractive Index1.4800 (estimate)
Log P1 at 20.1℃ and pH6.6-6.8

Safety & Handling

Danger
GHS06· ToxicGHS07· Irritant

Hazard Statements

H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P316Get emergency medical help immediately.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off immediately all contaminated clothing and wash it before reuse.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29122900
WGK (Germany)1