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Nordihydroguaiaretic acid

CAS Number
500-38-9
EC Number
207-903-0
Chemical Formula
C18H22O4
Molecular Weight
302.4 g/mol

Description

Nordihydroguaiaretic acid (CAS 500-38-9 ), commonly identified in procurement as NDGA, is a naturally derived phenolic antioxidant extracted from the creosote bush. It functions as a potent lipid oxidation inhibitor and stabilizer across food, pharmaceutical, and cosmetic manufacturing. In food processing, NDGA delays rancidity in fats, oils, and lipid-rich formulations where oxidative stability directly affects shelf life and product quality. Pharmaceutical formulators incorporate it as an antioxidant excipient to protect active ingredients. It is used to protect lipid-based drug delivery systems from oxidative degradation during storage. In personal care and cosmetic manufacturing, it is used in creams, lotions, and suncare formulations for both antioxidant protection and UV stabilization. Research and specialty chemical buyers also source NDGA as a reference standard or active compound in investigational formulations targeting oxidative stress pathways. This versatile compound is essential for maintaining the integrity of sensitive chemical structures. Nordihydroguaiaretic acid is supplied as a fine crystalline powder. It is available in research-grade and technical-grade specifications, with high-purity grades typically exceeding ninety-eight percent purity for specialized use. High-purity grades are offered for pharmaceutical and analytical applications. Packaging ranges from small quantities for laboratory and formulation development to bulk supply for industrial use, ensuring flexibility for various procurement needs. Contact us for supply of Nordihydroguaiaretic acid Request Quote

Other Names (Synonyms)

NDGA | nordihydroguaretic acid | 2,3-bis(3,4-dihydroxybenzyl)butane | RefChem:854717 | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol | Norhydroguaiaretic acid | Norguaiaretic acid, dihydro- | 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point185.5 °C
Boiling Point363.4°C (rough estimate)
Density1.0772 (rough estimate)
Appearancelight yellow crystalline solid
ColorWhite to off-white
FormPowder
Water Solubilityslightly soluble
Refractive Index1.4230 (estimate)
Log P4.640 (est)

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29072990
Storage Class11 - Combustible Solids
WGK (Germany)3