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D-Propylene glycol

CAS Number
4254-15-3
EC Number
610-039-0
Chemical Formula
C3H8O2
Molecular Weight
76.09 g/mol

Description

D-Propylene glycol (CAS 4254-15-3 ), also known as E490 , is the stereochemically pure (S)-enantiomer of propylene glycol, distinct from the racemic form used in most industrial applications. It functions as a humectant, solvent, and stabilizer across personal care, pharmaceutical, and polymer manufacturing sectors. In cosmetic formulations, it is selected where enantiomeric purity influences sensory performance. This includes premium moisturizers and serums where regulatory positioning is critical. Pharmaceutical manufacturers use it as a solvent and co-solvent in oral, topical, and injectable preparations where stereochemical specifications are required. In polymer and resin systems, it acts as a chiral building block for cross-linking reactions and the synthesis of optically active polyesters. Coating and adhesive formulators incorporate it as a reactive intermediate. This allows for controlled curing behavior and specific chain geometry that affect final film properties. The product is supplied as a clear, colorless liquid in bulk and intermediate packaging formats for industrial use. Food-grade material is available under the E number designation, meeting relevant purity standards for use in regulated applications. Pharmaceutical-grade supply conforming to USP and Ph.Eur. specifications is accessible. These grades are suitable for GMP-compliant manufacturing environments. Our supply chain ensures consistent quality and documentation for all technical, food, and pharmaceutical applications globally. Contact us for supply of D-Propylene glycol Request Quote

Other Names (Synonyms)

(S)-propane-1,2-diol | (+)-1,2-Propanediol | (2S)-propane-1,2-diol | (s)-1,2-propanediol | E490

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-59 °C
Boiling Point91-92 °C @ Press: 14 Torr
Density1.0364 g/cm³ @ Temp: 20 °C
Flash Point225 °F
AppearanceColorless to light yellow liqui
ColorClear colorless
FormLiquid
Water Solubilitysoluble
Refractive Indexn 20/D 1.432(lit.)

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29053200
Storage Class10 - Combustible liquids
WGK (Germany)1