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Ethyl 3,4-dihydroxybenzoate

CAS Number
3943-89-3
EC Number
223-529-0
Chemical Formula
C9H10O4
Molecular Weight
182.17 g/mol

Description

Ethyl 3,4-dihydroxybenzoate (CAS 3943-89-3 ), also known as EDHB or protocatechuic acid ethyl ester, is a synthetic ester of protocatechuic acid used across pharmaceutical, food, and cosmetic applications. It functions as an antioxidant, antimicrobial preservative, and UV stabilizer, protecting formulations and finished products from oxidative and photochemical degradation. In pharmaceutical manufacturing, it is used to stabilize active ingredients. This compound helps extend shelf life in oral and topical dosage forms by preventing oxidation. Food and beverage producers incorporate it as an antioxidant and flavoring agent where its phenolic character contributes to stability. It is particularly effective in fat-containing systems for maintaining sensory profiles. Cosmetic and personal care formulators apply it in suncare and anti-aging products for its UV-absorbing and antioxidant properties. These characteristics help protect both the formulation and the skin substrate from environmental damage. It also functions as a broad-spectrum antimicrobial agent in preservation systems against bacteria and fungi. The material offers activity in both leave-on and rinse-off formulations. Ethyl 3,4-dihydroxybenzoate is supplied as a white to off-white crystalline powder available in various purity specifications. It is available in pharmaceutical-grade and technical-grade specifications to meet the requirements of different end markets. Packaging options typically range from laboratory quantities to bulk industrial supply. Contact us for supply of Ethyl 3,4-dihydroxybenzoate Request Quote

Other Names (Synonyms)

protocatechuic acid ethyl ester | EDHB | 3,4-dihydroxybenzoic acid ethyl ester | Ethyl protocatechuate | 4YGJ96WTBG | Benzoic acid, 3,4-dihydroxy-, ethyl ester

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point132-134 °C
Boiling Point275.56°C (rough estimate)
Density1.2481 (rough estimate)
Appearancepale yellow to beige crystalline powder
ColorPale yellow to beige
Odorat 100.00?%. phenolic
FormCrystalline Powder
Water SolubilityInsoluble in water. Soluble in ethanol.
Vapor Pressure0-9.4Pa at 20-120℃
Refractive Index1.4500 (estimate)
Log P1.4 at 35℃ and pH6.6

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29053990
WGK (Germany)3