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L-citrulline

CAS Number
372-75-8
EC Number
206-759-6
Chemical Formula
C6H13N3O3
Molecular Weight
175.19 g/mol

Description

L-Citrulline (CAS 372-75-8 ) is a non-essential amino acid naturally occurring in watermelon and produced endogenously in the urea cycle. In commercial applications, it functions as a precursor to L-arginine. It supports nitric oxide pathway activity that underpins its use across sports nutrition, pharmaceutical, and personal care formulations. In sports nutrition, it is a primary active ingredient in pre-workout powders. These capsules target exercise performance and muscle recovery. Pharmaceutical manufacturers use it as an active or supporting ingredient in formulations addressing urea cycle disorders and cardiovascular-related indications. In functional food and beverage development, it is incorporated into fortified drinks and nutritional bars where amino acid enrichment is a label claim. Personal care formulators include it in topical products. It is used for its moisture-retention contribution and its role in supporting skin barrier function. This product is supplied as a white crystalline powder for various industrial and commercial applications. Food-grade and USP -grade specifications are the most commonly traded forms. Food-grade material meets FCC standards for use in ingestible products and dietary supplement manufacturing. Bulk quantities are available for industrial formulation. Pharmaceutical-grade material is subject to tighter purity and testing requirements to ensure compliance with global regulatory standards for safety. Contact us for supply of L-citrulline Request Quote

Other Names (Synonyms)

δ-ureidonorvaline | α-amino-δ-ureidovaleric acid | N5-carbamoylornithine | N5-Carbamoyl-L-ornithine | N5-(Aminocarbonyl)ornithine | N(delta)-Carbamylornithine | N(5)-(Aminocarbonyl)-L-ornithine | L-2-Amino-5-ureidovaleric acid

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point235.5 °C
Boiling Point306.48°C (rough estimate)
Density1.384 g/cm³ (solid)
AppearanceWhite powder
ColorWhite
OdorOdorless
FormCrystals or Crystalline Powder
Water Solubility200 g/L (20 ºC)
Refractive Index26 ° (C=8, 6mol/L HCl)
Log P-3.190

Safety & Handling

Warning
GHS07· Irritant

Hazard Statements

H315Causes skin irritation
H319Causes serious eye irritation

Precautionary Statements

P264Wash … thoroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P321Specific treatment (see … on this label).
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29241900
Storage Class11 - Combustible Solids
WGK (Germany)3