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Solvents REACH

Hexafluoroisopropyl methyl ether

CAS Number
13171-18-1
EC Number
603-501-8
Chemical Formula
C4H4F6O
Molecular Weight
182.06 g/mol

Description

Hexafluoroisopropyl methyl ether (CAS 13171-18-1 ), also known as HFE-356mmz1, is a fluorinated ether solvent used in specialized pharmaceutical and chemical processing applications. Iso-indoklon is a recognized trade reference for this compound in anesthetic research contexts. Its fluorinated structure delivers low surface tension and selective solvency, making it a candidate solvent where conventional options are unsuitable. In pharmaceutical manufacturing, it functions as a reaction solvent for fluorine-containing active pharmaceutical ingredient synthesis. Its chemical inertness prevents unwanted side reactions during complex chemical processes. It has been investigated as an inhalation anesthetic agent, with historical research under the Iso-indoklon designation informing modern CNS-active compound development. Formulators working with specialty coatings or fluoropolymer systems use it as a carrier solvent where precise solvency control is required. Its low reactivity also supports use as a cleaning and rinsing solvent in precision manufacturing environments. This compound is particularly effective when handling sensitive pharmaceutical equipment that requires non-reactive cleaning agents. Hexafluoroisopropyl methyl ether is supplied as a clear liquid, typically in research and specialty chemical quantities. It is available at high-purity grades suited to pharmaceutical research and synthesis applications. Packaging ranges from small laboratory quantities to bulk supply depending on supplier capability and end-use requirements for industrial applications. Contact us for supply of Hexafluoroisopropyl methyl ether Request Quote

Other Names (Synonyms)

Iso-indoklon | HFE-356mmz1 | 1,1,1,3,3,3-Hexafluoro-2-methoxypropane | 1,1,1,3,3,3-Hexafluoroisopropyl methyl ether | N8YMW3PAU7 | ETHER, METHYL 2,2,2-TRIFLUORO-1-(TRIFLUOROMETHYL)ETHYL | RefChem:409382 | 2-Methoxy-2H-perfluoropropane | HFIPE

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Boiling Point50.0-50.5 °C
Density1.39
Flash Point>93°C
ColorColorless to Almost colorless
FormLiquid:volatile
Vapor Pressure17.81-101.325kPa at 10-50.95℃
Refractive Index1.284
Log P1.807 at 25℃ and pH6-8

Safety & Handling

Danger
GHS02· FlammableGHS07· Irritant

Hazard Statements

H225Highly Flammable liquid and vapor
H315Causes skin irritation
H319Causes serious eye irritation

Precautionary Statements

P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P264Wash … thoroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P321Specific treatment (see … on this label).
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P352IF ON SKIN: Wash with plenty of water.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P235Store in a well-ventilated place. Keep cool.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code2909191800
UN Number3334