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Tetrahydrofuran

CAS Number
109-99-9
EC Number
203-726-8
Chemical Formula
C4H8O
Molecular Weight
72.11 g/mol

Description

Tetrahydrofuran (CAS 109-99-9 ), commonly known as THF or oxolane, is a cyclic ether solvent with exceptional miscibility across both polar and non-polar systems. It dissolves a broad range of polymers, resins, and active compounds. This versatile solvent handles materials that resist other common liquids, making it a go-to choice for demanding formulation and synthesis work. In pharmaceutical manufacturing, it is used as a reaction solvent and extraction medium. Its ability to solvate organolithium and Grignard reagents is critical to process chemistry during API synthesis. PVC adhesives and coatings rely on this chemical as the primary solvent, enabling strong substrate bonding in pipe fittings. It is also utilized in footwear and industrial laminates. It functions as a polymerization solvent in the production of polytetramethylene ether glycol (PTMEG), a key intermediate for spandex fibers and polyurethane elastomers. In analytical and QC laboratories, it serves as a standard HPLC mobile phase component for separating polymers and pharmaceutical compounds. The product is supplied as a clear liquid in drums, IBCs, and bulk tanker quantities. Anhydrous and stabilized grades are the most common commercial forms, with stabilizer-free variants available for sensitive synthesis applications. Technical and reagent-grade specifications are standard for industrial use. HPLC-grade is available for laboratory and analytical procurement. Our material meets rigorous industry requirements to ensure consistent performance across all manufacturing and research applications. Contact us for supply of Tetrahydrofuran Request Quote

Other Names (Synonyms)

tetramethylene oxide | Oxolane | diethylene oxide | Cyclotetramethylene oxide | butylene oxide | butane alpha,delta-oxide | Butane a,D-oxide | 1,4-epoxybutane | THF

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point-108.3 °C
Boiling Point65 °C @ Press: 760 Torr
Density0.8892 g/cm³ @ Temp: 20 °C
Flash Point>230 °F
AppearanceTetrahydrofuran is a colorless liquid. Ethereal odor. The Odor Threshold is listed @ 3.8 (3M), 20-50 ppm, and 31 ppm.
Color<10(APHA)
OdorEthereal, detectable at 2 to 50 ppm
FormLiquid
Water Solubilitymiscible
Vapor Pressure<0.01 mm Hg ( 25 °C)
Refractive Indexn 20/D 1.465
pH7-8 (200g/l, H2O, 20℃)
Log P0.45 at 25℃

Safety & Handling

Danger
GHS02· FlammableGHS07· IrritantGHS08· Health Hazard

Hazard Statements

H225Highly Flammable liquid and vapor
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H336May cause drowsiness or dizziness
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
H371May cause damage to organs
H372Causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P203Obtain, consult and follow expert instructions for use.
P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233Keep container tightly closed.
P240Ground and bond container and receiving equipment.
P241Use explosion-proof equipment.
P242Use non-sparking tools.
P243Take action to prevent static discharges.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P317Get emergency medical help.
P318IF exposed or concerned, get medical advice.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P378Use … for extinction.
P233Store in a well-ventilated place. Keep container tightly closed.
P235Store in a well-ventilated place. Keep cool.
P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29321100
UN Number2924
ADR Class3
Packing GroupII
Storage Class3 - Flammable liquids
WGK (Germany)1