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Mandelic acid

CAS Number
90-64-2
EC Number
202-007-6
Chemical Formula
C8H8O3
Molecular Weight
152.15 g/mol

Description

Mandelic acid (CAS 90-64-2 ), also known as phenylglycolic acid, is an alpha-hydroxy acid derived from bitter almonds that functions as a pharmaceutical intermediate, preservative, and skin-active ingredient. It is used across pharmaceutical synthesis, cosmetic formulation, and specialty chemical manufacturing where controlled exfoliation, antimicrobial activity, or chiral building block chemistry is required. In pharmaceutical manufacturing, it serves as a chiral intermediate in the synthesis of active ingredients including antibiotics, anticoagulants, and antispasmodics, where its optical isomers are resolved. Cosmetic formulators incorporate it into chemical peel systems and leave-on exfoliant products, where its larger molecular size relative to glycolic acid allows for a more controlled skin penetration profile. This characteristic makes it particularly suited to sensitive skin formulations. As a preservative and pH buffer, it is used in urinary tract preparations and topical antimicrobial products. In specialty resins and surface treatment chemistry, it functions as a wetting and adhesion modifier. Mandelic acid is supplied as a white crystalline powder for various industrial uses. Standard grades include pharmaceutical-grade ( USP / BP ) for drug synthesis and cosmetic-grade material for personal care applications. Technical-grade material is available for research. Contact us for supply of Mandelic acid Request Quote

Other Names (Synonyms)

phenylhydroxyacetic acid | phenylglycolic acid | paramandelic acid | DL-mandelic acid | DL-hydroxy(phenyl)acetic acid | DL-amygdalic acid | amygdalic acid | alpha-hydroxyphenylacetic acid

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

Physical Properties

Melting Point119 °C
Boiling Point203 °C @ Press: 15 Torr
Density1.29 g/cm³
AppearanceWhite crystalline powder
ColorWhite
Odorfaint odor
FormCrystals or Crystalline Powder
Water Solubility150 g/L (20 ºC)
Vapor Pressure0.01 Pa (50 °C)
Refractive Index1.4810 (estimate)
pH2.3 (10g/l, H2O)
Log P0.5 at 23℃

Safety & Handling

Danger
GHS05· CorrosiveGHS07· Irritant

Hazard Statements

H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary Statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash … thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P317Get emergency medical help.
P319Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container in accordance with local regulations.
P265Wash … thoroughly after handling.
P317Get emergency medical help.
P352IF ON SKIN: Wash with plenty of water.
P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317Get emergency medical help.
P317If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P364Take off contaminated clothing and wash it before reuse.
P233Store in a well-ventilated place. Keep container tightly closed.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29181990
Storage Class13 - Non Combustible Solids
WGK (Germany)3